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Literature DB >> 8755499

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

A Ruf¹, J Mennissier de Murcia, G de Murcia, G E Schulz.

Abstract

The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase; NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] with and without a nicotinamide-analogue inhibitor have been elucidated. Because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy. The inhibitor shows the nicotinamide site and also suggests the adenosine site. The enzyme is structurally related to bacterial ADP-ribosylating toxins but contains an additional alpha-helical domain that is suggested to relay the activation signal issued on binding to damaged DNA.

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Year: 1996 PMID： 8755499 PMCID： PMC38770 DOI： 10.1073/pnas.93.15.7481

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

29 in total

1. Improved methods for building protein models in electron density maps and the location of errors in these models.

Authors: T A Jones; J Y Zou; S W Cowan; M Kjeldgaard
Journal: Acta Crystallogr A Date: 1991-03-01 Impact factor: 2.290

2. The crystal structure of diphtheria toxin.

Authors: S Choe; M J Bennett; G Fujii; P M Curmi; K A Kantardjieff; R J Collier; D Eisenberg
Journal: Nature Date: 1992-05-21 Impact factor: 49.962

3. Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.

Authors: E Ben-Hur; H Utsumi; M M Elkind
Journal: Radiat Res Date: 1984-03 Impact factor: 2.841

4. Subunit assembly and active site location in the structure of glutamate dehydrogenase.

Authors: P J Baker; K L Britton; P C Engel; G W Farrants; K S Lilley; D W Rice; T J Stillman
Journal: Proteins Date: 1992-01

5. NAD(+)-dependent repair of damaged DNA by human cell extracts.

Authors: M S Satoh; G G Poirier; T Lindahl
Journal: J Biol Chem Date: 1993-03-15 Impact factor: 5.157

6. Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor.

Authors: J S Sebolt-Leopold; S V Scavone
Journal: Int J Radiat Oncol Biol Phys Date: 1992 Impact factor: 7.038

7. Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide.

Authors: C E Bell; D Eisenberg
Journal: Biochemistry Date: 1996-01-30 Impact factor: 3.162

8. Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.

Authors: M J Suto; W R Turner; C M Arundel-Suto; L M Werbel; J S Sebolt-Leopold
Journal: Anticancer Drug Des Date: 1991-05

9. Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells.

Authors: C M Arundel-Suto; S V Scavone; W R Turner; M J Suto; J S Sebolt-Leopold
Journal: Radiat Res Date: 1991-06 Impact factor: 2.841

10. Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.

Authors: M Domenighini; C Montecucco; W C Ripka; R Rappuoli
Journal: Mol Microbiol Date: 1991-01 Impact factor: 3.979

66 in total

10. Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites.

Authors: Matthias Altmeyer; Simon Messner; Paul O Hassa; Monika Fey; Michael O Hottiger
Journal: Nucleic Acids Res Date: 2009-04-16 Impact factor: 16.971

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

1. Improved methods for building protein models in electron density maps and the location of errors in these models.

2. The crystal structure of diphtheria toxin.

3. Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.

4. Subunit assembly and active site location in the structure of glutamate dehydrogenase.

5. NAD(+)-dependent repair of damaged DNA by human cell extracts.

6. Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor.

7. Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide.

8. Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.

9. Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells.

10. Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.

1. Crystal structure of human ADP-ribose transferase ARTD15/PARP16 reveals a novel putative regulatory domain.

Review 2. Structural dynamics in DNA damage signaling and repair.

3. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.

Review 4. Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy.

5. PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

Review 6. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

Review 7. Novel bacterial ADP-ribosylating toxins: structure and function.

Review 8. Functions of the poly(ADP-ribose) polymerase superfamily in plants.

9. Aerolysin and pertussis toxin share a common receptor-binding domain.

10. Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites.