Literature DB >> 9205257

In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound.

M D Bednarski1, J W Lee, M R Callstrom, K C Li.   

Abstract

Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.

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Year:  1997        PMID： 9205257     DOI： 10.1148/radiology.204.1.9205257

Source DB:  PubMed          Journal:  Radiology        ISSN： 0033-8419            Impact factor:   11.105


  17 in total

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