Literature DB >> 920169

Bilirubin inhibits hexose-monophosphate shunt activity of phagocytosing neutrophils.

Y H Thong, V Rencis.   

Abstract

Neutrophil hexose monophosphate (H.M.P.) shunt activity was measured by the conversion of 14C-1-glucose to 14CO2 during ingestion of polystyrene latex particles. Unconjugated bilrubin at the concentration of 1 X 10(5) M was found to markedly inhibit H.M.P. shunt activity. Since H.M.P. shunt activity of neutrophils is an important prerequisite of microbicidal function, it is suggested that jaundiced newborns may be more susceptible to bacterial infections.

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Year:  1977        PMID: 920169     DOI: 10.1111/j.1651-2227.1977.tb07985.x

Source DB:  PubMed          Journal:  Acta Paediatr Scand        ISSN: 0001-656X


  11 in total

Review 1.  The immunosuppressive effects of bilirubin.

Authors:  V Vĕtvicka; P Síma; I Miler; M Bilej
Journal:  Folia Microbiol (Praha)       Date:  1991       Impact factor: 2.099

2.  The stimulatory effect of bilirubin on phagocytic activity.

Authors:  M Bilej; V Vĕtvicka; P Síma
Journal:  Folia Microbiol (Praha)       Date:  1989       Impact factor: 2.099

3.  Defects in serum attractant activity in different types of chronic liver disease.

Authors:  A G Yousif-Kadaru; I A Rajkovic; R J Wyke; R Williams
Journal:  Gut       Date:  1984-01       Impact factor: 23.059

4.  The in vitro cytotoxic effect of bilirubin on human lymphocytes and granulocytes.

Authors:  I Miler; M Indrová; J Bubeník; J Vondrácek
Journal:  Folia Microbiol (Praha)       Date:  1985       Impact factor: 2.099

5.  The effect of bilirubin on the Fc receptor expression and phagocytic activity of mouse peritoneal macrophages.

Authors:  V Vĕtvicka; I Miler; P Síma; L Táborský; L Fornůsek
Journal:  Folia Microbiol (Praha)       Date:  1985       Impact factor: 2.099

6.  Bilirubin inhibits the chemotactic activity of human polymorphonuclear leukocytes in vitro.

Authors:  I Miler; J Vondrácek; L Hromádková
Journal:  Folia Microbiol (Praha)       Date:  1981       Impact factor: 2.099

7.  The bactericidal activity of sera of healthy neonates and of newborns with hyperbilirubinaemia to Escherichia coli.

Authors:  I Miler; J Vondrácek; L Hromádková
Journal:  Folia Microbiol (Praha)       Date:  1979       Impact factor: 2.099

8.  The suppressive effect of continuous infusion of bilirubin on the immune response in mice.

Authors:  P Síma; J Malá; I Miler; R Hodr; E Truxová
Journal:  Folia Microbiol (Praha)       Date:  1980       Impact factor: 2.099

9.  The effect of bilirubin on the phagocytic activity of mouse peripheral granulocytes and monocytes in vivo.

Authors:  I Miler; V Vĕtvicka; P Síma; L Táborský
Journal:  Folia Microbiol (Praha)       Date:  1985       Impact factor: 2.099

10.  Suppression of lymphocyte and neutrophil functions by Pseudomonas aeruginosa mucoid exopolysaccharide (alginate): reversal by physicochemical, alginase, and specific monoclonal antibody treatments.

Authors:  G T Mai; W K Seow; G B Pier; J G McCormack; Y H Thong
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

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