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Literature DB >> 4007709

The effect of bilirubin on the phagocytic activity of mouse peripheral granulocytes and monocytes in vivo.

I Miler, V Vĕtvicka, P Síma, L Táborský.

Abstract

Using an in vitro phagocytic assay with synthetic 2-hydroxyethylmethacrylate copolymer particles, the phagocytic activity of leukocytes of bilirubin-treated mice (85 and 170 mumol/L in 0.5 mL intraperitoneally) was studied. Bilirubin treatment significantly stimulated the phagocytosis of both peripheral blood granulocytes and monocytes; the increase of phagocytosis persisted for 6 h after bilirubin injection. The potential immunostimulating and/or immunotoxic effect of bilirubin is discussed.

Entities: Chemical Species

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Year: 1985 PMID： 4007709

Source DB: PubMed Journal: Folia Microbiol (Praha) ISSN： 0015-5632 Impact factor: 2.099

19 in total

1. Functional polymeric microspheres based on 2-hydroxyethyl methacrylate for immunochemical studies.

Authors: A Rembaum; S P Yen; E Cheong; S Wallace; R S Molday; I L Gordon; W J Dreyer
Journal: Macromolecules Date: 1976 Mar-Apr Impact factor: 5.985

2. [Neonatal hyperbilirubinemia. Its relation to the immunological response capacity of the newborn infant].

Authors: E Díaz del Casrillo
Journal: Gac Med Mex Date: 1973-02 Impact factor: 0.302

3. The development of immunological factors in infants with hyperbilirubinemia.

Authors: Z Nejedlá
Journal: Pediatrics Date: 1970-01 Impact factor: 7.124

4. Effect of bilirubin on the fungicidal capacity of human neutrophils.

Authors: Y H Thong; D Ness; A Ferrante
Journal: Sabouraudia Date: 1979-06

5. Effect of bilirubin on an in vitro correlate of cell-mediated immunity--the migration inhibition test.

Authors: J Svejcar; I Miler; J Pekárek
Journal: J Clin Lab Immunol Date: 1984-03

6. [The effect of neonatal hyperbilirubinemia on the morphology of lymphocyte nucleoli].

Authors: M Slavíková; I Miler
Journal: Cesk Pediatr Date: 1982-05

Review 7. [The influence of hyperbilirubinemia on immunity in the newborn and the immunosuppressive effect of bilirubin in experiments in vivo and in vitro].

Authors: I Miler
Journal: Cesk Pediatr Date: 1980-07

4. Intracellular accumulation of unconjugated bilirubin inhibits phytohemagglutin-induced proliferation and interleukin-2 production of human lymphocytes.

Authors: Y Haga; M A Tempero; D Kay; R K Zetterman
Journal: Dig Dis Sci Date: 1996-07 Impact factor: 3.199

4 in total

The effect of bilirubin on the phagocytic activity of mouse peripheral granulocytes and monocytes in vivo.

1. Functional polymeric microspheres based on 2-hydroxyethyl methacrylate for immunochemical studies.

2. [Neonatal hyperbilirubinemia. Its relation to the immunological response capacity of the newborn infant].

3. The development of immunological factors in infants with hyperbilirubinemia.

4. Effect of bilirubin on the fungicidal capacity of human neutrophils.

5. Effect of bilirubin on an in vitro correlate of cell-mediated immunity--the migration inhibition test.

6. [The effect of neonatal hyperbilirubinemia on the morphology of lymphocyte nucleoli].

Review 7. [The influence of hyperbilirubinemia on immunity in the newborn and the immunosuppressive effect of bilirubin in experiments in vivo and in vitro].

8. The mechanism of bilirubin toxicity studied with purified respiratory enzyme and tissue culture systems.

9. The suppressive effect of continuous infusion of bilirubin on the immune response in mice.

10. Phagocytosis of human blood leukocytes: a simple micromethod.

Review 1. The immunosuppressive effects of bilirubin.

2. The stimulatory effect of bilirubin on phagocytic activity.

3. The effect of bilirubin on the Fc receptor expression and phagocytic activity of mouse peritoneal macrophages.

4. Intracellular accumulation of unconjugated bilirubin inhibits phytohemagglutin-induced proliferation and interleukin-2 production of human lymphocytes.