Literature DB >> 191877

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets.

J E Tateson, S Moncada, J R Vane.   

Abstract

Prostacyclin (PGX) strikingly increases cyclic AMP concentrations in human platelets. Prostacyclin is approximately 10 times more active than PGD2, 30 times more active than PGE1 and more than 1000 times more active than its stable end product, 6-oxo-PGF1alpha. These results correlate well with the anti-aggregating activity of prostacyclin, compared with PGE1 and PGD2.

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Year:  1977        PMID: 191877     DOI: 10.1016/0090-6980(77)90019-3

Source DB:  PubMed          Journal:  Prostaglandins        ISSN: 0090-6980


  98 in total

1.  Internalization and down-regulation of the prostacyclin receptor in human platelets.

Authors:  S Giovanazzi; M R Accomazzo; O Letari; D Oliva; S Nicosia
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

Review 2.  Adventures in vascular biology: a tale of two mediators.

Authors:  S Moncada
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-05-29       Impact factor: 6.237

3.  Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man.

Authors:  W Krause; T Krais
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

4.  Prostaglandin I2 and the nitric oxide donor molsidomine have synergistic effects on thromboresistance in man.

Authors:  H Sinzinger; F Rauscha; J O'Grady; P Fitscha
Journal:  Br J Clin Pharmacol       Date:  1992-03       Impact factor: 4.335

5.  Classification of prostaglandin receptors based on coupling to signal transduction systems.

Authors:  S Muallem; B S Merritt; J Green; C R Kleeman; D T Yamaguchi
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

6.  Failure of epoprostenol (prostacyclin, PGI2) to inhibit platelet aggregation and to prevent restenosis after coronary angioplasty: results of a randomised placebo controlled trial.

Authors:  A H Gershlick; D Spriggins; S W Davies; Y D Syndercombe Court; J Timmins; A D Timmis; M T Rothman; C Layton; R Balcon
Journal:  Br Heart J       Date:  1994-01

7.  Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells.

Authors:  J M Harlan; K S Callahan
Journal:  J Clin Invest       Date:  1984-08       Impact factor: 14.808

8.  Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators.

Authors:  D Salvemini; M G Currie; V Mollace
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

9.  cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

Authors:  M A Moro; R J Russel; S Cellek; I Lizasoain; Y Su; V M Darley-Usmar; M W Radomski; S Moncada
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

10.  Thrombin-induced platelet secretion. Further evidence for a specific pathway.

Authors:  M A Shuman; M Botney; J W Fenton
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

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