Literature DB >> 918546

Elevated fecal levels of endogenous pancreatic endopeptidases after antibiotic treatment.

A Borgström, S Genell, K Ohlsson.   

Abstract

Feces from normal and antibiotic-treated persons were analyzed for the content of immunoreactive trypsin and elastase. In the control group the mean concentration of immunoreactive trypsin was 13 microgram per g feces as compared to 147 in the antibiotic-treated group. Elastase was demonstrable in only 3 of 30 samples in the control group but in 20 of 26 in the antibiotic-treated group. The decreased inactivation of pancreatic proteases must depend on an altered intestinal microflora. The results suggest that reestablishment of a normal enteric flora may take months after the short time oral administration of antibiotics.

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Year:  1977        PMID： 918546     DOI： 10.3109/00365527709181329

Source DB:  PubMed          Journal:  Scand J Gastroenterol        ISSN： 0036-5521            Impact factor:   2.423


  11 in total

1.  Luminal trypsin induces enteric nerve-mediated anion secretion in the mouse cecum.

Authors:  Osamu Ikehara; Hisayoshi Hayashi; Toshiharu Waguri; Izumi Kaji; Shin-ichiro Karaki; Atsukazu Kuwahara; Yuichi Suzuki
Journal:  J Physiol Sci       Date:  2014-01-14       Impact factor: 2.781

2.  May bacterial or pancreatic proteases play a critical role in inflammatory bowel disease?

Authors:  Xiaofa Qin
Journal:  World J Gastroenterol       Date:  2014-09-21       Impact factor: 5.742

Review 3.  Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 5. Stool enzyme measurements.

Authors:  E J Boyd; K G Wormsley
Journal:  Int J Pancreatol       Date:  1988-03

4.  Colonic absorption and bioavailability of the pentapeptide metkephamid in the rat.

Authors:  P Langguth; G Breves; A Stöckli; H P Merkle; S Wolffram
Journal:  Pharm Res       Date:  1994-11       Impact factor: 4.200

Review 5.  Exocrine pancreatic function tests.

Authors:  P G Lankisch
Journal:  Gut       Date:  1982-09       Impact factor: 23.059

6.  Fecal pancreatic elastase 1 in the work up of patients with chronic diarrhea.

Authors:  G Masoero; C Zaffino; C Laudi; L Lombardo; R Rocca; L Gallo; P Della Monica; A Pera
Journal:  Int J Pancreatol       Date:  2000-12

Review 7.  Interventions for the control of diarrhoeal diseases among young children: chemoprophylaxis.

Authors:  I de Zoysa; R G Feachem
Journal:  Bull World Health Organ       Date:  1985       Impact factor: 9.408

Review 8.  Role of gut in xenobiotic metabolism.

Authors:  O Hänninen; P Lindström-Seppä; K Pelkonen
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

9.  Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit.

Authors:  David Tooth; Klara Garsed; Gulzar Singh; Luca Marciani; Ching Lam; Imogen Fordham; Annie Fields; Rawinder Banwait; Melanie Lingaya; Robert Layfield; Maggie Hastings; Peter Whorwell; Robin Spiller
Journal:  Gut       Date:  2013-08-02       Impact factor: 23.059

10.  Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis.

Authors:  Hongsup Yoon; Monika Schaubeck; Ilias Lagkouvardos; Andreas Blesl; Stephanie Heinzlmeir; Hannes Hahne; Thomas Clavel; Suchita Panda; Christina Ludwig; Bernhard Kuster; Chaysavanh Manichanh; Patrizia Kump; Dirk Haller; Gabriele Hörmannsperger
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2018-05-29
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