BACKGROUND: Protection from thyroid carcinoma due to certain dietary factors was suggested by several studies, but the findings were relatively inconsistent. The role of micronutrients has not yet been systematically analyzed. To investigate the relationship between micronutrient intake and thyroid carcinoma risk, the authors used data from a case-control study conducted in northern Italy between 1986 and 1992. METHODS: The study included 399 incident, histologically confirmed thyroid carcinoma cases and 617 controls admitted to the hospital for acute, nonneoplastic, nonhormone-related diseases. RESULTS: Retinol intake showed a direct association with thyroid carcinoma risk, with odds ratios (ORs) of 1.39 (95% confidence Interval [CI], 0.9-2.0) in the third quartile of consumption and 1.52 (95% CI, 1.0-2.3) in the highest quartile, whereas beta-carotene had an inverse relationship, with ORs of 0.63 (95% CI, 0.4-0.9) in the third quartile of consumption and 0.58 (95% CI, 0.4-0.9) in the highest quartile compared with the lowest quartile. Some protection was observed for measures of vitamin C intake (with an OR of 0.72) and vitamin E (with an OR of 0.67) for the highest quartile of consumption, although the estimates were not statistically significant, and were reduced after adjustment for beta-carotene intake. No clear pattern in risk appeared for vitamin D, lolate, calcium, thiamin, or riboflavin. The inverse relationship between beta-carotene and thyroid carcinoma was observed in both papillary and follicular carcinomas. CONCLUSIONS: In this study, a significant inverse association between beta-carotene and thyroid carcinoma was observed, and some protection against thyroid carcinoma from vitamins C and E was also suggested.
BACKGROUND: Protection from thyroid carcinoma due to certain dietary factors was suggested by several studies, but the findings were relatively inconsistent. The role of micronutrients has not yet been systematically analyzed. To investigate the relationship between micronutrient intake and thyroid carcinoma risk, the authors used data from a case-control study conducted in northern Italy between 1986 and 1992. METHODS: The study included 399 incident, histologically confirmed thyroid carcinoma cases and 617 controls admitted to the hospital for acute, nonneoplastic, nonhormone-related diseases. RESULTS: Retinol intake showed a direct association with thyroid carcinoma risk, with odds ratios (ORs) of 1.39 (95% confidence Interval [CI], 0.9-2.0) in the third quartile of consumption and 1.52 (95% CI, 1.0-2.3) in the highest quartile, whereas beta-carotene had an inverse relationship, with ORs of 0.63 (95% CI, 0.4-0.9) in the third quartile of consumption and 0.58 (95% CI, 0.4-0.9) in the highest quartile compared with the lowest quartile. Some protection was observed for measures of vitamin C intake (with an OR of 0.72) and vitamin E (with an OR of 0.67) for the highest quartile of consumption, although the estimates were not statistically significant, and were reduced after adjustment for beta-carotene intake. No clear pattern in risk appeared for vitamin D, lolate, calcium, thiamin, or riboflavin. The inverse relationship between beta-carotene and thyroid carcinoma was observed in both papillary and follicular carcinomas. CONCLUSIONS: In this study, a significant inverse association between beta-carotene and thyroid carcinoma was observed, and some protection against thyroid carcinoma from vitamins C and E was also suggested.
Authors: Raul Zamora-Ros; Virginie Béraud; Silvia Franceschi; Valerie Cayssials; Konstantinos K Tsilidis; Marie-Christine Boutron-Ruault; Elisabete Weiderpass; Kim Overvad; Anne Tjønneland; Anne K Eriksen; Fabrice Bonnet; Aurélie Affret; Verena Katzke; Tilman Kühn; Heiner Boeing; Antonia Trichopoulou; Elisavet Valanou; Anna Karakatsani; Giovanna Masala; Sara Grioni; Maria Santucci de Magistris; Rosario Tumino; Fulvio Ricceri; Guri Skeie; Christine L Parr; Susana Merino; Elena Salamanca-Fernández; Maria-Dolores Chirlaque; Eva Ardanaz; Pilar Amiano; Martin Almquist; Isabel Drake; Joakim Hennings; Maria Sandström; H B As Bueno-de-Mesquita; Petra H Peeters; Kay-Thee Khaw; Nicholas J Wareham; Julie A Schmidt; Aurora Perez-Cornago; Dagfinn Aune; Elio Riboli; Nadia Slimani; Augustin Scalbert; Isabelle Romieu; Antonio Agudo; Sabina Rinaldi Journal: Int J Cancer Date: 2017-07-24 Impact factor: 7.396
Authors: Grégoire B Morand; Sabrina Daniela da Silva; Michael P Hier; Moulay A Alaoui-Jamali Journal: Front Oncol Date: 2014-11-04 Impact factor: 6.244
Authors: Giuseppe Bellastella; Lorenzo Scappaticcio; Francesco Caiazzo; Maria Tomasuolo; Raffaela Carotenuto; Mariangela Caputo; Stefania Arena; Paola Caruso; Maria Ida Maiorino; Katherine Esposito Journal: Nutrients Date: 2022-10-04 Impact factor: 6.706
Authors: Lara Lima-Antoine; Julianna Lys de Sousa Alves Neri; Thaisa Cristina Tavares de Melo; Isabela Samária Fernandes Leite; Diego Marques da Costa Santos; Jéssica Nayara Góes de Araújo; Ana Gabriella da Costa Lemos Silva; Nathália Kelly de Araújo; Carlos C de Oliveira Ramos; Sheila Ramos de Miranda Henriques Tarrapp; Andre Ducati Luchessi; Clélia de Oliveira Lyra; Karla Danielly da Silva Ribeiro; Vivian Nogueira Silbiger Journal: Eur J Clin Nutr Date: 2021-07-06 Impact factor: 4.016