Lara Lima-Antoine1,2, Julianna Lys de Sousa Alves Neri1, Thaisa Cristina Tavares de Melo3, Isabela Samária Fernandes Leite3, Diego Marques da Costa Santos4, Jéssica Nayara Góes de Araújo5, Ana Gabriella da Costa Lemos Silva1, Nathália Kelly de Araújo6, Carlos C de Oliveira Ramos7, Sheila Ramos de Miranda Henriques Tarrapp8, Andre Ducati Luchessi5,6,9,10, Clélia de Oliveira Lyra1, Karla Danielly da Silva Ribeiro1, Vivian Nogueira Silbiger11,12,13,14. 1. Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. 2. Sorbonne Université, Inserm UMRS_938, Centre de Recherche Saint-Antoine, Paris, France. 3. Laboratory of Bioanalysis and Molecular Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil. 4. Postgraduate Program of genetics and molecular biology, Federal University of Pará, Belém, Brazil. 5. Northeast Biotechnology Network (RENORBIO), Graduate Program in Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil. 6. Postgraduate Program of Healthy Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. 7. Division of Pathology, Hospital Liga Norte Riograndense Contra o Câncer, Natal, Brazil. 8. Division of Head and Neck Surgery, Liga Norte Riograndense Contra o Câncer Hospital, Natal, Brazil. 9. Postgraduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. 10. Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil. 11. Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br. 12. Northeast Biotechnology Network (RENORBIO), Graduate Program in Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br. 13. Postgraduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br. 14. Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br.
Abstract
BACKGROUND/ OBJECTIVES: Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients. SUBJECTS/ METHODS: We applied a cross-sectional study (2017-2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24-hr dietary recalls. RESULTS: Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion (p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension (p = 0.013) and lymph node metastasis (p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis. CONCLUSIONS: A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients.
BACKGROUND/ OBJECTIVES: Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients. SUBJECTS/ METHODS: We applied a cross-sectional study (2017-2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24-hr dietary recalls. RESULTS: Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion (p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension (p = 0.013) and lymph node metastasis (p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis. CONCLUSIONS: A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients.