Literature DB >> 9168011

A dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens.

A R Cunningham1, G Klopman, H S Rosenkranz.   

Abstract

Using two independent analyses, it is demonstrated that natural (e.g., estradiol) and some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding to specific receptors and may, in fact, differentiate harmful from beneficial estrogens.

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Year:  1997        PMID： 9168011      PMCID： PMC1469899          DOI： 10.1289/ehp.97105s3665

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  10 in total

Review 1.  International Commission for Protection Against Environmental Mutagens and Carcinogens. Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE.

Authors:  G Klopman; H S Rosenkranz
Journal:  Mutat Res       Date:  1994-02-01       Impact factor: 2.433

2.  Identification of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens and antiestrogens.

Authors:  H S Rosenkranz; A Cunningham; G Klopman
Journal:  Mutagenesis       Date:  1996-01       Impact factor: 3.000

Review 3.  Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

Authors:  L J Lerner; V C Jordan
Journal:  Cancer Res       Date:  1990-07-15       Impact factor: 12.701

4.  A study of the structural basis of the carcinogenicity of tamoxifen, toremifene and their metabolites.

Authors:  A Cunningham; G Klopman; H S Rosenkranz
Journal:  Mutat Res       Date:  1996-01-17       Impact factor: 2.433

5.  The carcinogenicity of diethylstilbestrol: structural evidence for a non-genotoxic mechanism.

Authors:  A Cunningham; G Klopman; H S Rosenkranz
Journal:  Arch Toxicol       Date:  1996       Impact factor: 5.153

6.  Bis(4-hydroxyphenyl)[2-(phenoxysulfonyl)phenyl]methane: isolation and structure elucidation of a novel estrogen from commercial preparations of phenol red (phenolsulfonphthalein)

Authors:  R D Bindal; J A Katzenellenbogen
Journal:  J Med Chem       Date:  1988-10       Impact factor: 7.446

Review 7.  Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982.

Authors:  L S Gold; M de Veciana; G M Backman; R Magaw; P Lopipero; M Smith; M Blumenthal; R Levinson; L Bernstein; B N Ames
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

8.  The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989.

Authors:  L S Gold; N B Manley; T H Slone; G B Garfinkel; L Rohrbach; B N Ames
Journal:  Environ Health Perspect       Date:  1993-04       Impact factor: 9.031

9.  Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987.

Authors:  L S Gold; T H Slone; G M Backman; S Eisenberg; M Da Costa; M Wong; N B Manley; L Rohrbach; B N Ames
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031

10.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031
  10 in total
  2 in total

1.  Effects of soy or milk protein during a high-fat feeding challenge on oxidative stress, inflammation, and lipids in healthy men.

Authors:  Christina G Campbell; Blakely D Brown; Danielle Dufner; William G Thorland
Journal:  Lipids       Date:  2006-03       Impact factor: 1.880

2.  Rapid estrogen receptor-α signaling mediated by ERK activation regulates vascular tone in male and ovary-intact female mice.

Authors:  Seong Chul Kim; Austin C Boese; Matthew H Moore; Rea M Cleland; Lin Chang; Patrice Delafontaine; Ke-Jie Yin; Jean-Pyo Lee; Milton H Hamblin
Journal:  Am J Physiol Heart Circ Physiol       Date:  2017-09-08       Impact factor: 4.733
  2 in total

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