| Literature DB >> 8975634 |
A Cunningham1, G Klopman, H S Rosenkranz.
Abstract
An analysis of the structure of diethylstilbestrol (DES) indicates that neither DES nor any of its metabolites are potential mutagens. Moreover, the present analyses suggest (a) that the observed carcinogenic spectrum of DES reflects the activity of metabolic intermediates and (b) that the carcinogenicity of DES in mice is due to the presence of a 6 A geometric descriptor that appears to be related to an estrogen receptor.Entities:
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Year: 1996 PMID： 8975634 DOI： 10.1007/s002040050285
Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153