| Literature DB >> 9164922 |
B M Segal1, D M Klinman, E M Shevach.
Abstract
The development and exacerbation of autoimmune diseases are associated with antecedent infectious illness. Microbial products such as LPS, bacterial DNA, or oligonucleotides containing an unmethylated cytosine-guanine dinucleotide have cytokine modulating properties. These products converted quiescent myelin basic protein-specific T cells into effector cells capable of transferring experimental allergic encephalomyelitis. The disease-promoting properties of the microbial products were solely dependent on their capacity to induce the production of IL-12.Entities:
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Year: 1997 PMID： 9164922
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422