Literature DB >> 16113339

CpG oligodeoxynucleotides increase the susceptibility of normal mice to infection by Candida albicans.

Shuichi Ito1, Joao Pedras-Vasconcelos, Dennis M Klinman.   

Abstract

Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.

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Year:  2005        PMID： 16113339      PMCID： PMC1231092          DOI： 10.1128/IAI.73.9.6154-6156.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

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