AIM: To assess the effect of insulin-like growth factor II (IGF-II) on proliferation of hepatocellular carcinoma (HCC) cells. METHODS: Expression of IGF-II mRNA and protein was detected in 10 archival HCC specimens using in situ hybridisation and immunohistochemistry, respectively. Expression of the Ki-67 antigen, a proliferation marker, was determined immunohistochemically on the same sections. RESULTS: Increased expression of IGF-II mRNA and protein was detected in five of the 10 HCCs in cells located at the periphery of tumour nests. The pattern of localisation of IGF-II was almost identical with that of Ki-67 antigen. CONCLUSIONS: Most of the Ki-67 antigen positive cells co-expressed IGF-II, suggesting that IGF-II may act as an autocrine or paracrine growth factor, and may play an important role in the development of HCC.
AIM: To assess the effect of insulin-like growth factor II (IGF-II) on proliferation of hepatocellular carcinoma (HCC) cells. METHODS: Expression of IGF-II mRNA and protein was detected in 10 archival HCC specimens using in situ hybridisation and immunohistochemistry, respectively. Expression of the Ki-67 antigen, a proliferation marker, was determined immunohistochemically on the same sections. RESULTS: Increased expression of IGF-II mRNA and protein was detected in five of the 10 HCCs in cells located at the periphery of tumour nests. The pattern of localisation of IGF-II was almost identical with that of Ki-67 antigen. CONCLUSIONS: Most of the Ki-67 antigen positive cells co-expressed IGF-II, suggesting that IGF-II may act as an autocrine or paracrine growth factor, and may play an important role in the development of HCC.
Authors: G Nardone; M Romano; A Calabrò; P V Pedone; I de Sio; M Persico; G Budillon; C B Bruni; A Riccio; R Zarrilli Journal: Hepatology Date: 1996-06 Impact factor: 17.425
Authors: A D'Errico; W F Grigioni; M Fiorentino; P Baccarini; E Lamas; S De Mitri; G Gozzetti; A M Mancini; C Brechot Journal: Pathol Int Date: 1994-02 Impact factor: 2.534
Authors: C E Rogler; D Yang; L Rossetti; J Donohoe; E Alt; C J Chang; R Rosenfeld; K Neely; R Hintz Journal: J Biol Chem Date: 1994-05-13 Impact factor: 5.157
Authors: A C Moses; S P Nissley; P A Short; M M Rechler; R M White; A B Knight; O Z Higa Journal: Proc Natl Acad Sci U S A Date: 1980-06 Impact factor: 11.205
Authors: Nalo Hamilton; Diana Marquez-Garban; Vei H Mah; Yahya Elshimali; David Elashoff; Edward B Garon; Jaydutt Vadgama; Richard Pietras Journal: Crit Rev Oncog Date: 2015
Authors: Nicholas A Shackel; Peter H McGuinness; Catherine A Abbott; Mark D Gorrell; Geoffrey W McCaughan Journal: Am J Pathol Date: 2002-02 Impact factor: 4.307
Authors: Liang-Hao Ding; Yongjia Yu; Elijah F Edmondson; Michael M Weil; Laurentiu M Pop; Maureen McCarthy; Robert L Ullrich; Michael D Story Journal: Sci Rep Date: 2021-07-07 Impact factor: 4.379