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Literature DB >> 11577168

IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

Abstract

Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance.

Entities: Disease Gene

Mesh：

Substances：

Year: 2001 PMID： 11577168 PMCID： PMC1187083 DOI： 10.1136/mp.54.5.285

Source DB: PubMed Journal: Mol Pathol ISSN： 1366-8714

62 in total

1. The product of the imprinted H19 gene is an oncofetal RNA.

Authors: I Ariel; S Ayesh; E J Perlman; G Pizov; V Tanos; T Schneider; V A Erdmann; D Podeh; D Komitowski; A S Quasem; N de Groot; A Hochberg
Journal: Mol Pathol Date: 1997-02

2. Serum levels of insulin-like growth factor-I, -II and insulin-like growth factor binding proteins -2 and -3 in children with acute lymphoblastic leukaemia.

Authors: K L Mohnike; U Kluba; U Mittler; V Aumann; P Vorwerk; W F Blum
Journal: Eur J Pediatr Date: 1996-02 Impact factor: 3.183

3. Circulating insulin-like growth factor II and colorectal adenomas.

Authors: A G Renehan; J E Painter; D O'Halloran; W S Atkin; C S Potten; S T O'Dwyer; S M Shalet
Journal: J Clin Endocrinol Metab Date: 2000-09 Impact factor: 5.958

Review 4. The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis.

Authors: H Werner; D Le Roith
Journal: Crit Rev Oncog Date: 1997

5. Effect of breast surgery on serum levels of insulin-like growth factors (IGF-I, IGF-II, and IGF binding protein-3) in women with benign and malignant breast lesions.

Authors: I M Holdaway; A E Lethaby; B H Mason; V Singh; J E Harman; M MacCormick; I D Civil
Journal: Ann Surg Oncol Date: 2001 Jan-Feb Impact factor: 5.344

6. Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: correlation with cancer antigen 125 and tumor-associated trypsin inhibitor.

Authors: A Flyvbjerg; O Mogensen; B Mogensen; O S Nielsen
Journal: J Clin Endocrinol Metab Date: 1997-07 Impact factor: 5.958

7. Can measurements of IGF-1 and IGFBP-3 improve the sensitivity of prostate-cancer screening?

Authors: A Wolk; S O Andersson; C S Mantzoros; D Trichopoulos; H O Adami
Journal: Lancet Date: 2000-12-02 Impact factor: 79.321

8. Evaluation of plasma insulin-like growth factor binding protein-2 as a marker for adrenocortical tumors.

Authors: N Boulle; E Baudin; C Gicquel; A Logié; J Bertherat; A Penfornis; X Bertagna; J P Luton; M Schlumberger; Y Le Bouc
Journal: Eur J Endocrinol Date: 2001-01 Impact factor: 6.664

9. Insulin-like growth factor (IGF)-I, -II and IGF binding protein-2 (IGFBP-2) in the plasma of children with Wilms' tumour.

Authors: W Zumkeller; J Schwander; C D Mitchell; D J Morrell; P N Schofield; M A Preece
Journal: Eur J Cancer Date: 1993 Impact factor: 9.162

10. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

Authors: C E Rogler; D Yang; L Rossetti; J Donohoe; E Alt; C J Chang; R Rosenfeld; K Neely; R Hintz
Journal: J Biol Chem Date: 1994-05-13 Impact factor: 5.157

11 in total

1. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1.

Authors: Wen-jing Ruan; Jie Lin; En-ping Xu; Fang-ying Xu; Yu Ma; Hong Deng; Qiong Huang; Bing-jian Lv; Hu Hu; Jing Cui; Mei-juan Di; Jian-kang Dong; Mao-de Lai
Journal: J Zhejiang Univ Sci B Date: 2006-11 Impact factor: 3.066

2. Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer.

Authors: R Mehrian-Shai; C D Chen; T Shi; S Horvath; S F Nelson; J K V Reichardt; C L Sawyers
Journal: Proc Natl Acad Sci U S A Date: 2007-03-19 Impact factor: 11.205

3. Insulin like growth factor binding protein 4 promotes GBM progression and regulates key factors involved in EMT and invasion.

Authors: V R Praveen Kumar; Priyanka Sehgal; Balram Thota; Shilpa Patil; Vani Santosh; Paturu Kondaiah
Journal: J Neurooncol Date: 2014-01-07 Impact factor: 4.130

4. Anti-inflammatory activity of soy and tea in prostate cancer prevention.

Authors: Anna Hsu; Tammy M Bray; Emily Ho
Journal: Exp Biol Med (Maywood) Date: 2010-06

5. Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling.

Authors: Mohammad Saleem; Imtiyaz Murtaza; Rohinton S Tarapore; Yewseok Suh; Vaqar Mustafa Adhami; Jeremy James Johnson; Imtiaz Ahmad Siddiqui; Naghma Khan; Mohammad Asim; Bilal Bin Hafeez; Mohammed Talha Shekhani; Benyi Li; Hasan Mukhtar
Journal: Carcinogenesis Date: 2009-02-20 Impact factor: 4.944

6. Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice.

Authors: Archana Thakur; Aliccia Bollig; Jiusheng Wu; Dezhong J Liao
Journal: Mol Cancer Date: 2008-01-24 Impact factor: 27.401

7. Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.

Authors: Antimo Naspi; Vincenzo Panasiti; Franco Abbate; Vincenzo Roberti; Valeria Devirgiliis; Michela Curzio; Martina Borghi; Francesco Lozupone; Simone Carotti; Sergio Morini; Eugenio Gaudio; Stefano Calvieri; Paola Londei
Journal: PLoS One Date: 2014-06-06 Impact factor: 3.240