Literature DB >> 9151888

Transformation by bovine papillomavirus type 1 E6 is independent of transcriptional activation by E6.

R Ned1, S Allen, S Vande Pol.   

Abstract

We have generated mutants of bovine papillomavirus type 1 E6 (BE6) that are defective for transcriptional activation and have analyzed these mutants for transformation of contact-inhibited cells and association with the mammalian protein E6-AP. These BE6 mutants demonstrate that transformation by BE6 does not require transcriptional activation and that association of BE6 with E6-AP is a function separable from transcriptional activation by BE6. Association of BE6 with E6-AP appears to be necessary but not sufficient for transformation by BE6. In addition, the mutational analysis of BE6 demonstrates that transactivation, transformation, and association with E6-AP all require sequences throughout the BE6 gene, indicating that the papillomavirus E6 proteins do not have a simple domain structure.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9151888      PMCID： PMC191716     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Improved retroviral vectors for gene transfer and expression.

Authors:  A D Miller; G J Rosman
Journal:  Biotechniques       Date:  1989-10       Impact factor: 1.993

Review 2.  The papillomavirus E2 regulatory proteins.

Authors:  A A McBride; H Romanczuk; P M Howley
Journal:  J Biol Chem       Date:  1991-10-05       Impact factor: 5.157

3.  Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

Authors:  G Walter; R Ruediger; C Slaughter; M Mumby
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

Review 4.  Interactions between papillomavirus proteins and tumor suppressor gene products.

Authors:  K H Vousden
Journal:  Adv Cancer Res       Date:  1994       Impact factor: 6.242

5.  Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

Authors:  D B Smith; K S Johnson
Journal:  Gene       Date:  1988-07-15       Impact factor: 3.688

6.  Mutational analysis of bovine papillomavirus E6 gene.

Authors:  K H Vousden; E J Androphy; J T Schiller; D R Lowy
Journal:  J Virol       Date:  1989-05       Impact factor: 5.103

7.  Transcriptional activation by the papillomavirus E6 zinc finger oncoprotein.

Authors:  C Lamberti; L C Morrissey; S R Grossman; E J Androphy
Journal:  EMBO J       Date:  1990-06       Impact factor: 11.598

8.  Negative regulation of the bovine papillomavirus E5, E6, and E7 oncogenes by the viral E1 and E2 genes.

Authors:  S B Vande Pol; P M Howley
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103

9.  A rapid permeabilization procedure for accurate quantitative determination of beta-galactosidase activity in yeast cells.

Authors:  F Kippert
Journal:  FEMS Microbiol Lett       Date:  1995-05-01       Impact factor: 2.742

10.  Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein.

Authors:  J J Chen; C E Reid; V Band; E J Androphy
Journal:  Science       Date:  1995-07-28       Impact factor: 47.728
View more
  5 in total

1.  Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase.

Authors:  S Nakagawa; J M Huibregtse
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

2.  Identification of a second transforming function in bovine papillomavirus type 1 E6 and the role of E6 interactions with paxillin, E6BP, and E6AP.

Authors:  K Das; J Bohl; S B Vande Pol
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

3.  Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins.

Authors:  J Bohl; B Hull; S B Vande Pol
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

Review 4.  Regulation of apoptosis by the papillomavirus E6 oncogene.

Authors:  Ting-Ting Li; Li-Na Zhao; Zhi-Guo Liu; Ying Han; Dai-Ming Fan
Journal:  World J Gastroenterol       Date:  2005-02-21       Impact factor: 5.742

5.  Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

Authors:  Katia Zanier; Sebastian Charbonnier; Abdellahi Ould M'hamed Ould Sidi; Alastair G McEwen; Maria Giovanna Ferrario; Pierre Poussin-Courmontagne; Vincent Cura; Nicole Brimer; Khaled Ould Babah; Tina Ansari; Isabelle Muller; Roland H Stote; Jean Cavarelli; Scott Vande Pol; Gilles Travé
Journal:  Science       Date:  2013-02-08       Impact factor: 47.728
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.