Literature DB >> 2539522

Mutational analysis of bovine papillomavirus E6 gene.

K H Vousden1, E J Androphy, J T Schiller, D R Lowy.   

Abstract

The bovine papillomavirus E6 gene can independently transform mouse C127 cells. To characterize E6 in greater detail, we created 16 site-directed mutations in E6, including substitution mutations in the cysteine codons of the four Cys-X-X-Cys motifs that are conserved in all papillomavirus E6 proteins. Proteins mutated in six of the seven cysteines tested, as well as those lacking the nonconserved C-terminus, were stable in transfected cells but were unable to induce morphological transformation, indicating that these amino acids play an important role in the function of E6.

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Year:  1989        PMID： 2539522      PMCID： PMC250653     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

1.  E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene.

Authors:  J T Schiller; W C Vass; K H Vousden; D R Lowy
Journal:  J Virol       Date:  1986-01       Impact factor: 5.103

2.  Repression of bovine papilloma virus replication is mediated by a virally encoded trans-acting factor.

Authors:  L Berg; M Lusky; A Stenlund; M R Botchan
Journal:  Cell       Date:  1986-08-29       Impact factor: 41.582

3.  Metal-dependent folding of a single zinc finger from transcription factor IIIA.

Authors:  A D Frankel; J M Berg; C O Pabo
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

Review 4.  Zinc fingers: gilt by association.

Authors:  R M Evans; S M Hollenberg
Journal:  Cell       Date:  1988-01-15       Impact factor: 41.582

5.  Rapid and efficient site-specific mutagenesis without phenotypic selection.

Authors:  T A Kunkel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

6.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors:  P J Southern; P Berg
Journal:  J Mol Appl Genet       Date:  1982

7.  Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.

Authors:  C C Baker; W C Phelps; V Lindgren; M J Braun; M A Gonda; P M Howley
Journal:  J Virol       Date:  1987-04       Impact factor: 5.103

8.  Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

Authors:  D Smotkin; F O Wettstein
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

9.  Identification of the protein encoded by the E6 transforming gene of bovine papillomavirus.

Authors:  E J Androphy; J T Schiller; D R Lowy
Journal:  Science       Date:  1985-10-25       Impact factor: 47.728

10.  Dissociation of transforming and trans-activation functions for bovine papillomavirus type 1.

Authors:  Y C Yang; B A Spalholz; M S Rabson; P M Howley
Journal:  Nature       Date:  1985 Dec 12-18       Impact factor: 49.962
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  9 in total

1.  Transformation by bovine papillomavirus type 1 E6 is independent of transcriptional activation by E6.

Authors:  R Ned; S Allen; S Vande Pol
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

2.  Mutational analysis of simian virus 40 small-t antigen.

Authors:  P Jog; B Joshi; V Dhamankar; M J Imperiale; J Rutila; K Rundell
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

3.  Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1.

Authors:  X Tong; W Boll; T Kirchhausen; P M Howley
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

4.  A point mutational analysis of human papillomavirus type 16 E7 protein.

Authors:  C Edmonds; K H Vousden
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

5.  The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

Authors:  X Tong; P M Howley
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-29       Impact factor: 11.205

6.  Transcriptional activation by the papillomavirus E6 zinc finger oncoprotein.

Authors:  C Lamberti; L C Morrissey; S R Grossman; E J Androphy
Journal:  EMBO J       Date:  1990-06       Impact factor: 11.598

Review 7.  Regulation of apoptosis by the papillomavirus E6 oncogene.

Authors:  Ting-Ting Li; Li-Na Zhao; Zhi-Guo Liu; Ying Han; Dai-Ming Fan
Journal:  World J Gastroenterol       Date:  2005-02-21       Impact factor: 5.742

8.  Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein.

Authors:  J B Harry; F O Wettstein
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

9.  Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16.

Authors:  C Desaintes; S Hallez; P Van Alphen; A Burny
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103
  9 in total

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