Literature DB >> 9149531

Silencers and locus control regions: opposite sides of the same coin.

R T Kamakaka1.   

Abstract

Whether or not genes are in an active or a repressed state in a cell depends on the relative effect of gene silencers and locus control regions (LCRs). Here, we suggest that these elements act as binary switches; the state that prevails (activated or repressed) probably depends on a competition between protein complex formation and the stability of the complexes formed at either of the two elements.

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Year:  1997        PMID： 9149531     DOI： 10.1016/s0968-0004(96)10074-8

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  12 in total

Review 1.  Spatial organization of RNA polymerase II transcription in the nucleus.

Authors:  M N Szentirmay; M Sawadogo
Journal:  Nucleic Acids Res       Date:  2000-05-15       Impact factor: 16.971

2.  Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.

Authors:  M Bulger; J H van Doorninck; N Saitoh; A Telling; C Farrell; M A Bender; G Felsenfeld; R Axel; M Groudine; J H von Doorninck
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

3.  Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities.

Authors:  S Ghidelli; D Donze; N Dhillon; R T Kamakaka
Journal:  EMBO J       Date:  2001-08-15       Impact factor: 11.598

4.  Long-range communication between the silencers of HMR.

Authors:  Lourdes Valenzuela; Namrita Dhillon; Rudra N Dubey; Marc R Gartenberg; Rohinton T Kamakaka
Journal:  Mol Cell Biol       Date:  2008-01-14       Impact factor: 4.272

Review 5.  Regulation of gene expression: how can molecules make the right ventricle distinct from the left?

Authors:  R S Ross
Journal:  J Nucl Cardiol       Date:  1998 Nov-Dec       Impact factor: 5.952

Review 6.  Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Authors:  Ying Huang
Journal:  Nucleic Acids Res       Date:  2002-04-01       Impact factor: 16.971

7.  The boundaries of the silenced HMR domain in Saccharomyces cerevisiae.

Authors:  D Donze; C R Adams; J Rine; R T Kamakaka
Journal:  Genes Dev       Date:  1999-03-15       Impact factor: 11.361

8.  A fission yeast repression element cooperates with centromere-like sequences and defines a mat silent domain boundary.

Authors:  N Ayoub; I Goldshmidt; R Lyakhovetsky; A Cohen
Journal:  Genetics       Date:  2000-11       Impact factor: 4.562

9.  Sir- and silencer-independent disruption of silencing in Saccharomyces by Sas10p.

Authors:  R T Kamakaka; J Rine
Journal:  Genetics       Date:  1998-06       Impact factor: 4.562

10.  Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclin.

Authors:  Laurieann Casey; Erin E Patterson; Ulrika Müller; Catherine A Fox
Journal:  Mol Biol Cell       Date:  2007-11-28       Impact factor: 4.138
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