Literature DB >> 9131619

DNA enzymes.

R R Breaker1.   

Abstract

Biological catalysis is dominated by enzymes that are made of protein, but several distinct classes of catalytic RNAs are known to promote chemical transformations that are fundamental to cellular metabolism. Is biological catalysis limited only to these two biopolymers, or is DNA also capable of functioning as an enzyme in nature? To date, no DNA enzymes of natural origin have been found. However, an increasing number of catalytic DNAs, with characteristics that are similar to those of ribozymes, are being produced outside the confines of the cell. An assessment of the potential for structure formation by DNA leads to the conclusion that DNA might have considerable latent potential for enzymatic function.

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Year:  1997        PMID: 9131619     DOI: 10.1038/nbt0597-427

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN: 1087-0156            Impact factor:   54.908


  57 in total

1.  Structural diversity of self-cleaving ribozymes.

Authors:  J Tang; R R Breaker
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

2.  Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA.

Authors:  T Kuwabara; M Warashina; T Tanabe; K Tani; S Asano; K Taira
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

Review 3.  Gold nanoparticles in chemical and biological sensing.

Authors:  Krishnendu Saha; Sarit S Agasti; Chaekyu Kim; Xiaoning Li; Vincent M Rotello
Journal:  Chem Rev       Date:  2012-02-02       Impact factor: 60.622

4.  DNA computing circuits using libraries of DNAzyme subunits.

Authors:  Johann Elbaz; Oleg Lioubashevski; Fuan Wang; Françoise Remacle; Raphael D Levine; Itamar Willner
Journal:  Nat Nanotechnol       Date:  2010-05-30       Impact factor: 39.213

Review 5.  Colorimetric biosensors based on DNAzyme-assembled gold nanoparticles.

Authors:  Juewen Liu; Yi Lu
Journal:  J Fluoresc       Date:  2004-07       Impact factor: 2.217

6.  Zn2+-dependent deoxyribozymes that form natural and unnatural RNA linkages.

Authors:  Kelly A Hoadley; Whitney E Purtha; Amanda C Wolf; Amber Flynn-Charlebois; Scott K Silverman
Journal:  Biochemistry       Date:  2005-06-28       Impact factor: 3.162

Review 7.  Functional nucleic acid sensors.

Authors:  Juewen Liu; Zehui Cao; Yi Lu
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

8.  Mechanism for allosteric inhibition of an ATP-sensitive ribozyme.

Authors:  J Tang; R R Breaker
Journal:  Nucleic Acids Res       Date:  1998-09-15       Impact factor: 16.971

Review 9.  Metal ion sensors based on DNAzymes and related DNA molecules.

Authors:  Xiao-Bing Zhang; Rong-Mei Kong; Yi Lu
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2011       Impact factor: 10.745

10.  Depurination of N7-methylguanine by DNA glycosylase AlkD is dependent on the DNA backbone.

Authors:  Emily H Rubinson; Plamen P Christov; Brandt F Eichman
Journal:  Biochemistry       Date:  2013-10-07       Impact factor: 3.162

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