Literature DB >> 91313

Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine.

H G Johnson, M D Miller.   

Abstract

We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentration caused enhancement in this function. Evidence was obtained that L 10(-4) M may displace Ca++ from the cell membranes.

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Year:  1979        PMID： 91313     DOI： 10.1007/BF01966694

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  19 in total

1.  Refinements in the automated fluorometric histamine analysis system.

Authors:  R P Siraganian
Journal:  J Immunol Methods       Date:  1975-06       Impact factor: 2.303

2.  A method for the fluorometric assay of histamine in tissues.

Authors:  P A SHORE; A BURKHALTER; V H COHN
Journal:  J Pharmacol Exp Ther       Date:  1959-11       Impact factor: 4.030

3.  Concurrent inhibition by chlorpromazine of concanavalin A-induced lymphocyte aggregation and mitogenesis.

Authors:  R M Ferguson; J R Schmidtke; R L Simmons
Journal:  Nature       Date:  1975-08-28       Impact factor: 49.962

4.  Differential effects of chlorpromazine on the in vitro generation and effector function of cytotoxic lymphocytes.

Authors:  R M Ferguson; J R Schmidtke; R L Simmons
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307

Review 5.  The membrane actions of anesthetics and tranquilizers.

Authors:  P Seeman
Journal:  Pharmacol Rev       Date:  1972-12       Impact factor: 25.468

Review 6.  The role of calcium in the release of neurotransmitter substances and hormones.

Authors:  R P Rubin
Journal:  Pharmacol Rev       Date:  1970-09       Impact factor: 25.468

7.  Compound 48-80 decreases adenosine 3'5'-monophosphate formation in rat peritoneal mast cells.

Authors:  E Gillespie
Journal:  Experientia       Date:  1973-04-15

8.  Prevention of calcium ionophore-induced release of histamine in rat mast cells by disodium cromoglycate.

Authors:  H G Johnson; M K Bach
Journal:  J Immunol       Date:  1975-01       Impact factor: 5.422

9.  The mechanism of basophil histamine release induced by antigen and by the calcium ionophore A23187.

Authors:  L M Lichtenstein
Journal:  J Immunol       Date:  1975-06       Impact factor: 5.422

10.  Proceedings: Effect of lidocaine on compound 48/80-induced histamine release.

Authors:  W Kazimierczak; C Maśliński
Journal:  Agents Actions       Date:  1975-12
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  4 in total

1.  Inhibition of histamine release from human lung in vitro by antihistamines and related drugs.

Authors:  M K Church; C F Gradidge
Journal:  Br J Pharmacol       Date:  1980-08       Impact factor: 8.739

2.  Amitriptyline and prochlorperazine inhibit proinflammatory mediator release from human mast cells: possible relevance to chronic fatigue syndrome.

Authors:  Anthony Clemons; Magdalini Vasiadi; Duraisamy Kempuraj; Taxiarchis Kourelis; Gregory Vandoros; Theoharis C Theoharides
Journal:  J Clin Psychopharmacol       Date:  2011-06       Impact factor: 3.153

3.  Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells.

Authors:  F De Clerck; J Van Reempts; M Borgers
Journal:  Agents Actions       Date:  1981-05

4.  Effects of transforaminal injection for degenerative lumbar scoliosis combined with spinal stenosis.

Authors:  Hee-Seung Nam; Yong Bum Park
Journal:  Ann Rehabil Med       Date:  2011-08-31
  4 in total

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