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Literature DB >> 911658

Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.

Abstract

The relationship between the utilization of 3H-thymidine in situ ([3H]-TdR fractional incorporation or TFI) and tumour growth delay after treatment with various cytotoxic agents has been examined. It is shown that (a) it is not possible to predict tumour growth delay, or to select the most effective agent, from changes in TFI 1 day after treatment; (b) there is a good correlation between tumour growth delay and the time for recovery of TFI to the pretreatment level; (c) there is a relationship within a tumour line between the depression of TFI 4 days after treatment and growth dealy induced by the same treatment. This relationship appears to be independent of the mechanism by which the agent exerts its cytotoxic effect.

Entities: Chemical Disease Species

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Year: 1977 PMID： 911658 PMCID： PMC2025473 DOI： 10.1038/bjc.1977.179

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

12 in total

1. Commentary: screening for anti-cancer agents; the relative merits of in vitro and in vovo techniques.

Authors: T A Connors; B J Phillips
Journal: Biochem Pharmacol Date: 1975-12-15 Impact factor: 5.858

2. Effects of cis-dichlorodiammine platinum (II) on DNA synthesis in kidney and other tissues of normal and tumour-bearing rats.

Authors: D M Taylor; K D Tew; J D Jones
Journal: Eur J Cancer Date: 1976-04 Impact factor: 9.162

3. In vitro determination of thymidine-3H labeling index in human solid tumors.

Authors: R B Livingston; U Ambus; S L George; E J Freireich; J S Hart
Journal: Cancer Res Date: 1974-06 Impact factor: 12.701

4. Biochemical approaches to prediction of response in solid tumors.

Authors: W H Wolberg
Journal: Natl Cancer Inst Monogr Date: 1971-12

5. Growth inhibiting effects of cytotoxic agents on human tumor and tumor-bearing normal tissue in vitro.

Authors: F C Izsak; E Eylan; A Gazith; J Shapiro; S Naharin; C Raanani
Journal: Eur J Cancer Date: 1971-02 Impact factor: 9.162

6. Assessment of an in vitro screening test of cytotoxic agents in the treatment of advanced malignant disease.

Authors: T K Wheeler; P P Dendy; A Dawson
Journal: Oncology Date: 1974 Impact factor: 2.935

7. Cell population kinetics of transplanted and metastatic Lewis lung carcinoma.

Authors: L Simpson-Herren; A H Sanford; J P Holmquist
Journal: Cell Tissue Kinet Date: 1974-07

8. Determination of therapeutic index of drugs by in vitro sensitivity tests using human host and tumor cell suspensions.

Authors: G Tisman; V Herbert; H Edlis
Journal: Cancer Chemother Rep Date: 1973-02

6. Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.

Authors: J A Houghton; D M Taylor
Journal: Br J Cancer Date: 1978-02 Impact factor: 7.640

7. Growth characteristics of human colorectal tumours during serial passage in immune-deprived mice.

Authors: J A Houghton; D M Taylor
Journal: Br J Cancer Date: 1978-02 Impact factor: 7.640

Review 8. Human tumour xenografts: a critical appraisal.

Authors: G G Steel; M J Peckham
Journal: Br J Cancer Suppl Date: 1980-04

8 in total

Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.

1. Commentary: screening for anti-cancer agents; the relative merits of in vitro and in vovo techniques.

2. Effects of cis-dichlorodiammine platinum (II) on DNA synthesis in kidney and other tissues of normal and tumour-bearing rats.

3. In vitro determination of thymidine-3H labeling index in human solid tumors.

4. Biochemical approaches to prediction of response in solid tumors.

5. Growth inhibiting effects of cytotoxic agents on human tumor and tumor-bearing normal tissue in vitro.

6. Assessment of an in vitro screening test of cytotoxic agents in the treatment of advanced malignant disease.

7. Cell population kinetics of transplanted and metastatic Lewis lung carcinoma.

8. Determination of therapeutic index of drugs by in vitro sensitivity tests using human host and tumor cell suspensions.

9. Serial labeling index determination as a predictor of response in human solid tumors.

10. Walter Hubert lecture Chemotherapy of upper gastrointestinal carcinoma.

Review 1. Predictive tests in cancer chemotherapy. A reappraisal.

2. The mechanism of 67Ga uptake in animal and human tumours.

3. Serological aspects of rat tumour xenograft growth in athymic nude mice.

4. Assays of drug sensitivity for cells from human tumours: in vitro and in vivo tests on a xenografted tumour.

5. Serial cytogenetic studies of human colonic tumour xenografts.

6. Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.

7. Growth characteristics of human colorectal tumours during serial passage in immune-deprived mice.

Review 8. Human tumour xenografts: a critical appraisal.