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Literature DB >> 9108158

Long-range interaction between the P2.1 and P9.1 peripheral domains of the Tetrahymena ribozyme.

Abstract

The Tetrahymena ribozyme possesses peripheral domains, termed P9.1 and P9.2. They are nonessential in the mechanism of the catalytic reaction but contribute to enhance the catalytic activity of the ribozyme. It has been postulated that P9.1 is capable of forming Watson-Crick base pairings with another peripheral domain, P2.1. We report here the existence of long-range base pairings between the loop regions of these two domains and show that this interaction apparently plays a role in enhancing the catalytic activity of the ribozyme.

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Year: 1997 PMID： 9108158 PMCID： PMC146647 DOI： 10.1093/nar/25.9.1761

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

23 in total

1. Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis.

Authors: F Michel; E Westhof
Journal: J Mol Biol Date: 1990-12-05 Impact factor: 5.469

2. The guanosine binding site of the Tetrahymena ribozyme.

Authors: F Michel; M Hanna; R Green; D P Bartel; J W Szostak
Journal: Nature Date: 1989-11-23 Impact factor: 49.962

3. A simple and rapid method for generating a deletion by PCR.

Authors: Y Imai; Y Matsushima; T Sugimura; M Terada
Journal: Nucleic Acids Res Date: 1991-05-25 Impact factor: 16.971

4. New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme.

Authors: V Lehnert; L Jaeger; F Michel; E Westhof
Journal: Chem Biol Date: 1996-12

5. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity.

Authors: E T Barfod; T R Cech
Journal: Genes Dev Date: 1988-06 Impact factor: 11.361

6. Cloning and expression of the gene for bacteriophage T7 RNA polymerase.

Authors: P Davanloo; A H Rosenberg; J J Dunn; F W Studier
Journal: Proc Natl Acad Sci U S A Date: 1984-04 Impact factor: 11.205

7. Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5.

Authors: G F Joyce; G van der Horst; T Inoue
Journal: Nucleic Acids Res Date: 1989-10-11 Impact factor: 16.971

8. Phylogenetic position of some Chlorella species within the chlorococcales based upon complete small-subunit ribosomal RNA sequences.

Authors: V A Huss; M L Sogin
Journal: J Mol Evol Date: 1990-11 Impact factor: 2.395

Long-range interaction between the P2.1 and P9.1 peripheral domains of the Tetrahymena ribozyme.

1. Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis.

2. The guanosine binding site of the Tetrahymena ribozyme.

3. A simple and rapid method for generating a deletion by PCR.

4. New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme.

5. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity.

6. Cloning and expression of the gene for bacteriophage T7 RNA polymerase.

7. Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5.

8. Phylogenetic position of some Chlorella species within the chlorococcales based upon complete small-subunit ribosomal RNA sequences.

9. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups.

10. Reconstitution of a group I intron self-splicing reaction with an activator RNA.

1. Identification of antisense RNA stem-loops that inhibit RNA-protein interactions using a bacterial reporter system.

2. Predicting the secondary structures and tertiary interactions of 211 group I introns in IE subgroup.