Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The guanosine binding site of the Tetrahymena ribozyme.

Literature DB >> 2685606

The guanosine binding site of the Tetrahymena ribozyme.

F Michel¹, M Hanna, R Green, D P Bartel, J W Szostak.

Abstract

The self-splicing Group I introns have a highly specific binding site for the substrate guanosine. Mutant versions of the Tetrahymena ribozyme have been used in combination with guanosine analogues to identify the nucleotide in the ribozyme that is primarily responsible for recognition of the guanine base.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2685606 DOI： 10.1038/342391a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

Keyword Cloud
Cited

109 in total

1. An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.

Authors: A A Szewczak; L Ortoleva-Donnelly; M V Zivarts; A K Oyelere; A V Kazantsev; S A Strobel
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

2. Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme.

Authors: E L Christian; N M Kaye; M E Harris
Journal: RNA Date: 2000-04 Impact factor: 4.942

Review 3. Coupled nucleotide covariations reveal dynamic RNA interaction patterns.

Authors: A P Gultyaev; T Franch; K Gerdes
Journal: RNA Date: 2000-11 Impact factor: 4.942

4. Novel group I intron in the tRNA(Leu)(UAA) gene of a gamma-proteobacterium isolated from a deep subsurface environment.

Authors: Alexey A Vepritskiy; Inna A Vitol; Sandra A Nierzwicki-Bauer
Journal: J Bacteriol Date: 2002-03 Impact factor: 3.490

5. Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.

Authors: Aya Kitamura; Yutaka Muto; Satoru Watanabe; Insil Kim; Takuhiro Ito; Yoichi Nishiya; Kensaku Sakamoto; Takashi Ohtsuki; Gota Kawai; Kimitsuna Watanabe; Kazumi Hosono; Hiroshi Takaku; Etsuko Katoh; Toshimasa Yamazaki; Tan Inoue; Shigeyuki Yokoyama
Journal: RNA Date: 2002-04 Impact factor: 4.942

The guanosine binding site of the Tetrahymena ribozyme.

1. An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.

2. Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme.

Review 3. Coupled nucleotide covariations reveal dynamic RNA interaction patterns.

4. Novel group I intron in the tRNA(Leu)(UAA) gene of a gamma-proteobacterium isolated from a deep subsurface environment.

5. Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.

6. The ability to form full-length intron RNA circles is a general property of nuclear group I introns.

7. Mutagenesis of a light-regulated psbA intron reveals the importance of efficient splicing for photosynthetic growth.

8. Mutational evidence for competition between the P1 and the P10 helices of a mitochondrial group I intron.

9. The non-Watson-Crick base pairs and their associated isostericity matrices.

10. Lead cleavage sites in the core structure of group I intron-RNA.