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Literature DB >> 9087482

Fluconazole tolerance in clinical isolates of Cryptococcus neoformans.

K Venkateswarlu¹, M Taylor, N J Manning, M G Rinaldi, S L Kelly.

Abstract

Eleven isolates of Cryptococcus neoformans were investigated to determine the biochemical basis of their tolerance to fluconazole. The MICs of fluconazole for three isolates with low-level resistance were 3- to 6-fold higher than those for sensitive isolates, while the MICs for four isolates with high-level resistance were 100- to 200-fold higher than those for sensitive isolates. The level of ergosterol present in the isolates varied, and those which had relatively low levels of ergosterol were resistant to amphotericin B. Changes in the affinity of the target enzyme (sterol 14alpha-demethylase) and decreases in the cellular content of fluconazole seemed to be responsible for the resistance in isolates with low-level and high-level resistance, respectively.

Entities: Chemical Species

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Year: 1997 PMID： 9087482 PMCID： PMC163787

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

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Journal: FEMS Microbiol Lett Date: 1994-09-15 Impact factor: 2.742

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Journal: FEBS Lett Date: 1995-10-30 Impact factor: 4.124

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Journal: Biochem Biophys Res Commun Date: 1995-02-27 Impact factor: 3.575

24 in total

Review 1. Mechanisms of fungal resistance: an overview.

Authors: Maher M Balkis; Steven D Leidich; Pranab K Mukherjee; Mahmoud A Ghannoum
Journal: Drugs Date: 2002 Impact factor: 9.546

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Authors: Laura Rodero; Emilia Mellado; A Carolina Rodriguez; Angela Salve; Liliana Guelfand; Pedro Cahn; Manuel Cuenca-Estrella; Graciela Davel; Juan L Rodriguez-Tudela
Journal: Antimicrob Agents Chemother Date: 2003-11 Impact factor: 5.191

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Authors: Maria Manuel da S Azevedo; Luisa Cruz; Cidália Pina-Vaz; Acácio Gonçalves-Rodrigues
Journal: J Public Health Policy Date: 2016-02-11 Impact factor: 2.222

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Authors: Luiz R Basso; Charles E Gast; Igor Bruzual; Brian Wong
Journal: J Antimicrob Chemother Date: 2015-01-27 Impact factor: 5.790