Literature DB >> 14576140

G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate.

Laura Rodero1, Emilia Mellado, A Carolina Rodriguez, Angela Salve, Liliana Guelfand, Pedro Cahn, Manuel Cuenca-Estrella, Graciela Davel, Juan L Rodriguez-Tudela.   

Abstract

Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.

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Year:  2003        PMID： 14576140      PMCID： PMC253790          DOI： 10.1128/AAC.47.11.3653-3656.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Drug resistance in Cryptococcus neoformans.

Authors:  John R. Perfect; Gary M. Cox
Journal:  Drug Resist Updat       Date:  1999-08       Impact factor: 18.500

2.  Development of azole resistance during fluconazole maintenance therapy for AIDS-associated cryptococcal disease.

Authors:  G Friese; T Discher; R Füssle; A Schmalreck; J Lohmeyer
Journal:  AIDS       Date:  2001-11-23       Impact factor: 4.177

3.  CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.

Authors:  D G Higgins; P M Sharp
Journal:  Gene       Date:  1988-12-15       Impact factor: 3.688

4.  Involvement of multiple Cryptococcus neoformans strains in a single episode of cryptococcosis and reinfection with novel strains in recurrent infection demonstrated by random amplification of polymorphic DNA and DNA fingerprinting.

Authors:  A Casadevall; E D Spitzer
Journal:  J Clin Microbiol       Date:  1995-06       Impact factor: 5.948

5.  The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.

Authors:  S L Kelly; D C Lamb; J Loeffler; H Einsele; D E Kelly
Journal:  Biochem Biophys Res Commun       Date:  1999-08-19       Impact factor: 3.575

6.  Heterogeneous mechanisms of azole resistance in Candida albicans clinical isolates from an HIV-infected patient on continuous fluconazole therapy for oropharyngeal candidosis.

Authors:  M Martínez; J L López-Ribot; W R Kirkpatrick; S P Bachmann; S Perea; M T Ruesga; T F Patterson
Journal:  J Antimicrob Chemother       Date:  2002-03       Impact factor: 5.790

7.  Fluconazole tolerance in clinical isolates of Cryptococcus neoformans.

Authors:  K Venkateswarlu; M Taylor; N J Manning; M G Rinaldi; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

8.  Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents.

Authors:  D Sanglard; F Ischer; L Koymans; J Bille
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

9.  Persistence of initial infection in recurrent Cryptococcus neoformans meningitis.

Authors:  E D Spitzer; S G Spitzer; L F Freundlich; A Casadevall
Journal:  Lancet       Date:  1993-03-06       Impact factor: 79.321

10.  Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole.

Authors:  Brunella Posteraro; Maurizio Sanguinetti; Dominique Sanglard; Marilena La Sorda; Stefania Boccia; Lucio Romano; Giulia Morace; Giovanni Fadda
Journal:  Mol Microbiol       Date:  2003-01       Impact factor: 3.501
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  50 in total

1.  An overview about the medical use of antifungals in Portugal in the last years.

Authors:  Maria Manuel da S Azevedo; Luisa Cruz; Cidália Pina-Vaz; Acácio Gonçalves-Rodrigues
Journal:  J Public Health Policy       Date:  2016-02-11       Impact factor: 2.222

2.  Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding.

Authors:  Chunquan Sheng; Zhenyuan Miao; Haitao Ji; Jianzhong Yao; Wenya Wang; Xiaoying Che; Guoqiang Dong; Jiaguo Lü; Wei Guo; Wannian Zhang
Journal:  Antimicrob Agents Chemother       Date:  2009-05-26       Impact factor: 5.191

3.  Azole heteroresistance in Cryptococcus neoformans: emergence of resistant clones with chromosomal disomy in the mouse brain during fluconazole treatment.

Authors:  Edward Sionov; Yun C Chang; Kyung J Kwon-Chung
Journal:  Antimicrob Agents Chemother       Date:  2013-07-08       Impact factor: 5.191

Review 4.  Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Authors:  Leah E Cowen; William J Steinbach
Journal:  Eukaryot Cell       Date:  2008-03-28

5.  The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.

Authors:  Andrew G S Warrilow; Josie E Parker; Claire L Price; W David Nes; Edward P Garvey; William J Hoekstra; Robert J Schotzinger; Diane E Kelly; Steven L Kelly
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

Review 6.  Mechanisms of Antifungal Drug Resistance.

Authors:  Leah E Cowen; Dominique Sanglard; Susan J Howard; P David Rogers; David S Perlin
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-10       Impact factor: 6.915

7.  Cryptococcus neoformans Yop1 , an endoplasmic reticulum curvature-stabilizing protein, participates with Sey1 in influencing fluconazole-induced disomy formation.

Authors:  Popchai Ngamskulrungroj; Yun Chang; Bryan Hansen; Cliff Bugge; Elizabeth Fischer; Kyung J Kwon-Chung
Journal:  FEMS Yeast Res       Date:  2012-07-18       Impact factor: 2.796

8.  Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection.

Authors:  Donna M MacCallum; Alix Coste; Françoise Ischer; Mette D Jacobsen; Frank C Odds; Dominique Sanglard
Journal:  Antimicrob Agents Chemother       Date:  2010-01-19       Impact factor: 5.191

9.  Roles of Three Cryptococcus neoformans and Cryptococcus gattii Efflux Pump-Coding Genes in Response to Drug Treatment.

Authors:  Miwha Chang; Edward Sionov; Ami Khanal Lamichhane; Kyung J Kwon-Chung; Yun C Chang
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

10.  Novel mutations in CYP51B from Penicillium digitatum involved in prochloraz resistance.

Authors:  Jinlong Wang; Jinhui Yu; Jing Liu; Yongze Yuan; Na Li; Muqing He; Ting Qi; Geng Hui; Li Xiong; Deli Liu
Journal:  J Microbiol       Date:  2014-08-02       Impact factor: 3.422
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