Literature DB >> 7589528

Altered P450 activity associated with direct selection for fungal azole resistance.

T Joseph-Horne1, D Hollomon, R S Loeffler, S L Kelly.   

Abstract

Azole antifungals inhibit CYP51A1-mediated sterol 14 alpha-demethylation and the mechanism(s) of resistance to such compounds in Ustilago maydis were examined. The inhibition of growth was correlated with the accumulation of the substrate, 24-methylene-24,25-dihydrolanosterol (eburicol), and depletion of ergosterol. Mutants overcoming the effect of azole antifungal treatment exhibited a unique phenotype with leaky CYP51A1 activity which was resistant to inhibition. The results demonstrate that alterations at the level of inhibitor binding to the target site can produce azole resistance. Similar changes may account for fungal azole resistance phenomena in agriculture, and also in medicine where resistance has become a problem in immunocompromised patients suffering from AIDS.

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Year:  1995        PMID： 7589528     DOI： 10.1016/0014-5793(95)01102-k

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Itraconazole resistance in Aspergillus fumigatus.

Authors:  D W Denning; K Venkateswarlu; K L Oakley; M J Anderson; N J Manning; D A Stevens; D W Warnock; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

Review 2.  Azole resistance in Candida.

Authors:  D W Denning; G G Baily; S V Hood
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1997-04       Impact factor: 3.267

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4.  Fluconazole tolerance in clinical isolates of Cryptococcus neoformans.

Authors:  K Venkateswarlu; M Taylor; N J Manning; M G Rinaldi; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

5.  Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance.

Authors:  K Venkateswarlu; D W Denning; N J Manning; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

6.  Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents.

Authors:  D Sanglard; F Ischer; L Koymans; J Bille
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

7.  A novel ATP-binding cassette transporter involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum.

Authors:  R Nakaune; K Adachi; O Nawata; M Tomiyama; K Akutsu; T Hibi
Journal:  Appl Environ Microbiol       Date:  1998-10       Impact factor: 4.792

8.  Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.

Authors:  H Miyazaki; Y Miyazaki; A Geber; T Parkinson; C Hitchcock; D J Falconer; D J Ward; K Marsden; J E Bennett
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

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Authors:  Gabriela Felix Persinoti; Nalu Teixeira de Aguiar Peres; Tiago Rinaldi Jacob; Antonio Rossi; Ricardo Zorzetto Vêncio; Nilce Maria Martinez-Rossi
Journal:  BMC Genomics       Date:  2014-10-27       Impact factor: 3.969

10.  Micronized Copper Wood Preservatives: Efficacy of Ion, Nano, and Bulk Copper against the Brown Rot Fungus Rhodonia placenta.

Authors:  Chiara Civardi; Mark Schubert; Angelika Fey; Peter Wick; Francis W M R Schwarze
Journal:  PLoS One       Date:  2015-11-10       Impact factor: 3.240
  10 in total

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