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Literature DB >> 9063676

Biopharmaceutical aspects of lipid formulations of amphotericin B.

Abstract

To improve the clinical utility of amphotericin B (AmpB), several lipid-based formulations have been developed. The biopharmaceutical aspects related to the parenteral use of colloidal lipid particles as carriers of AmpB are reviewed here. The first part of the review provides an introduction to the parenteral use of colloidal particles for chemotherapy by addressing the concept of a particulate drug carrier system, the pharmaceutical technological issues, and the biological factors governing the potential and limitations of lipid particles for effective drug delivery. The second part is devoted to AmpB lipid formulations. The pharmaceutical characteristics of the various industrially produced formulations, their pharmacokinetics and possible mechanisms of action, and potential future developments are described.

Entities: Chemical

Mesh：

Substances：

Year: 1997 PMID： 9063676 DOI： 10.1007/bf01575123

Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267

36 in total

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Journal: Antimicrob Agents Chemother Date: 1995-09 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1989-01 Impact factor: 5.191

10 in total

1. Improved antifungal activity of amphotericin B-loaded TPGS-b-(PCL-ran-PGA) nanoparticles.

Authors: Xiaolong Tang; Ronghong Jiao; Chunmei Xie; Lifa Xu; Zhen Huo; Jingjing Dai; Yunyun Qian; Weiwen Xu; Wei Hou; Jiang Wang; Yong Liang
Journal: Int J Clin Exp Med Date: 2015-04-15

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Journal: Clin Microbiol Rev Date: 1999-04 Impact factor: 26.132

3. Compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations.

Authors: Andreas H Groll; Caron A Lyman; Vidmantas Petraitis; Ruta Petraitiene; Derek Armstrong; Diana Mickiene; Raul M Alfaro; Robert L Schaufele; Tin Sein; John Bacher; Thomas J Walsh
Journal: Antimicrob Agents Chemother Date: 2006-10 Impact factor: 5.191

Review 4. Newer antifungal agents.

Authors: Walid Abuhammour; Eyassu Habte-Gaber
Journal: Indian J Pediatr Date: 2004-03 Impact factor: 1.967

Review 5. Pharmacological properties of antifungal drugs with a focus on anidulafungin.

Authors: Teresita Mazzei; Andrea Novelli
Journal: Drugs Date: 2009 Impact factor: 9.546

6. Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis.

Authors: Gloria M González; Rolando Tijerina; Laura K Najvar; Rosie Bocanegra; Michael G Rinaldi; John R Graybill
Journal: Antimicrob Agents Chemother Date: 2004-06 Impact factor: 5.191