| Literature DB >> 26131089 |
Xiaolong Tang1, Ronghong Jiao2, Chunmei Xie3, Lifa Xu4, Zhen Huo4, Jingjing Dai4, Yunyun Qian4, Weiwen Xu3, Wei Hou5, Jiang Wang4, Yong Liang6.
Abstract
To develop amphotericin B-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles (PLGA-TPGS-AMB NPs) for fungal infection treatment, PLGA-TPGS NPs and PLGA NPs were synthesized by a modified double emulsion method and characterized in terms of size and size distribution, morphology and zeta potential. Drug encapsulation efficiency, in vitro drug release, and in vitro/vivo tests against Candida glabrata were completed. The data showed that both of the two AMB-loaded NPs (PLGA-AMB NPs, PLGA-TPGS-AMB NPs) achieved significantly higher level of antifungal effects than water suspended AMB. In comparison with PLGA-AMB NPs, PLGA-TPGS-AMB NPs had a stronger protective effect against candidiasis and gained an advantage of prolonged antifungal efficacy. In conclusion, PLGA-TPGS-AMB NPs system significantly improves AMB bioavailability by increasing the aqueous dispersibility and improving the antifungal activity. And this would be an excellent choice for the antifungal treatment of the entrapped drug because of its low toxicity and higher effectiveness.Entities:
Keywords: Antifungal; Candida glabrata; TPGS-b-(PCL-ran-PGA); amphotericin B; nanoparticle
Year: 2015 PMID： 26131089 PMCID： PMC4483864
Source DB: PubMed Journal: Int J Clin Exp Med ISSN： 1940-5901