| Literature DB >> 7081822 |
R L Taylor, D M Williams, P C Craven, J R Graybill, D J Drutz, W E Magee.
Abstract
Incorporation of amphotericin B into liposomes significantly altered its toxicity, tissue distribution, and efficacy. Compared with intravenously administered amphotericin B-desoxycholate, liposome-amphotericin B showed a reduced acute toxicity and a maximal tolerable dose 9 times greater than amphotericin B-desoxycholate. Liposome-amphotericin B also produced higher tissue and lower serum concentrations than amphotericin B-desoxycholate, and was significantly more effective in prolonging survival of mice infected with Histoplasma capsulatum.Entities:
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Year: 1982 PMID： 7081822 DOI： 10.1164/arrd.1982.125.5.610
Source DB: PubMed Journal: Am Rev Respir Dis ISSN： 0003-0805