| Literature DB >> 9054360 |
X He1, J P Saint-Jeannet, Y Wang, J Nathans, I Dawid, H Varmus.
Abstract
In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.Entities:
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Year: 1997 PMID： 9054360 DOI： 10.1126/science.275.5306.1652
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728