Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Wnt pathway antagonists and angiogenesis.

Literature DB >> 21204016

Wnt pathway antagonists and angiogenesis.

Abstract

Dysregulation of the Wnt pathway has been extensively studied in multiple diseases, including some angiogenic disorders. Wnt signaling activation is a major stimulator in pathological angiogenesis and thus, Wnt antagonists are believed to have therapeutic potential for neovascular disorders. Actually, some Wnt antagonists have been identified directly from the anti-angiogenic factor family. This review summarizes the recent progress toward understanding of the roles of Wnt pathway antagonists in angiogenic regulation and their mechanism of action, and exploring their therapeutic potential.

Entities: Disease

Mesh：

Substances：

Year: 2010 PMID： 21204016 PMCID： PMC4875116 DOI： 10.1007/s13238-010-0112-0

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

111 in total

1. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.

Authors: P W Finch; X He; M J Kelley; A Uren; R P Schaudies; N C Popescu; S Rudikoff; S A Aaronson; H E Varmus; J S Rubin
Journal: Proc Natl Acad Sci U S A Date: 1997-06-24 Impact factor: 11.205

2. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.

Authors: F Rijsewijk; M Schuermann; E Wagenaar; P Parren; D Weigel; R Nusse
Journal: Cell Date: 1987-08-14 Impact factor: 41.582

3. Identification of c-MYC as a target of the APC pathway.

Authors: T C He; A B Sparks; C Rago; H Hermeking; L Zawel; L T da Costa; P J Morin; B Vogelstein; K W Kinzler
Journal: Science Date: 1998-09-04 Impact factor: 47.728

4. Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex.

Authors: Takashi Shimokawa; Yoichi Furukawa; Michihiro Sakai; Meihua Li; Nobutomo Miwa; Yu-Min Lin; Yusuke Nakamura
Journal: Cancer Res Date: 2003-10-01 Impact factor: 12.701

5. Secreted frizzled-related protein 4: an angiogenesis inhibitor.

Authors: Ajit Muley; Syamantak Majumder; Gopi Krishna Kolluru; Steve Parkinson; Helena Viola; Livia Hool; Frank Arfuso; Ruth Ganss; Arun Dharmarajan; Suvro Chatterjee
Journal: Am J Pathol Date: 2010-01-07 Impact factor: 4.307

6. Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin.

Authors: Shahid Umar; Shubhashish Sarkar; Yu Wang; Pomila Singh
Journal: J Biol Chem Date: 2009-06-04 Impact factor: 5.157

7. Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.

Authors: Ying Chen; Yang Hu; Ti Zhou; Kevin K Zhou; Robert Mott; Mingyuan Wu; Michael Boulton; Timothy J Lyons; Guoquan Gao; Jian-xing Ma
Journal: Am J Pathol Date: 2009-11-05 Impact factor: 4.307

8. Angiogenesis: role of calcium-mediated signal transduction.

Authors: E C Kohn; R Alessandro; J Spoonster; R P Wersto; L A Liotta
Journal: Proc Natl Acad Sci U S A Date: 1995-02-28 Impact factor: 11.205

9. Frizzled6 controls hair patterning in mice.

Authors: Nini Guo; Charles Hawkins; Jeremy Nathans
Journal: Proc Natl Acad Sci U S A Date: 2004-05-28 Impact factor: 11.205

10. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300.

Authors: Min-Jung Ryu; Munju Cho; Jie-Young Song; Yeon-Sook Yun; Il-Whan Choi; Dong-Eun Kim; Byeoung-Soo Park; Sangtaek Oh
Journal: Biochem Biophys Res Commun Date: 2008-11-10 Impact factor: 3.575

18 in total

Review 1. Wnt Signaling in vascular eye diseases.

Authors: Zhongxiao Wang; Chi-Hsiu Liu; Shuo Huang; Jing Chen
Journal: Prog Retin Eye Res Date: 2018-12-01 Impact factor: 21.198

2. Oxidative stress upregulates Wnt signaling in human retinal microvascular endothelial cells through activation of disheveled.

Authors: Chi Zhang; Elizabeth Tannous; Jie J Zheng
Journal: J Cell Biochem Date: 2019-04-08 Impact factor: 4.429

3. Plasma and vitreous fluid levels of Dickkopf-1 in patients with diabetic retinopathy.

Authors: F Qiu; J He; Y Zhou; X Bai; G Wu; X Wang; Z Liu; Y Chen; J-X Ma; Z Liu
Journal: Eye (Lond) Date: 2014-01-10 Impact factor: 3.775

Review 4. Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure-function continuum with intrinsic disorder-based proteoforms.

Authors: Alexander V Fonin; April L Darling; Irina M Kuznetsova; Konstantin K Turoverov; Vladimir N Uversky
Journal: Cell Mol Life Sci Date: 2019-08-19 Impact factor: 9.261

5. Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling.

Authors: Kai Gong; Fangfang Zhou; Huizhe Huang; Yandao Gong; Long Zhang
Journal: Protein Cell Date: 2012-09-15 Impact factor: 14.870

9. Systems biology approach to identify alterations in the stem cell reservoir of subcutaneous adipose tissue in a rat model of diabetes: effects on differentiation potential and function.

Authors: Raquel Ferrer-Lorente; Maria Teresa Bejar; Monica Tous; Gemma Vilahur; Lina Badimon
Journal: Diabetologia Date: 2013-10-17 Impact factor: 10.122

Review 10. Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells.

Authors: Weiqiang Zhou; Guangdi Wang; Shanchun Guo
Journal: Biochim Biophys Acta Date: 2013-10-30