Literature DB >> 9045847

In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor.

J E Cronan1.   

Abstract

In vitro experiments point to fatty acyl coenzymes A (acyl-CoAs) rather than unesterified fatty acids as the small-molecule ligands regulating DNA binding by the FadR protein of Escherichia coli. To provide an in vivo test of this specificity, unesterified fatty acids were generated within the cellular cytosol. These fatty acids were found to be efficient modulators of FadR action only when the acids could be converted to acyl-CoAs.

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Year:  1997        PMID： 9045847      PMCID： PMC178900          DOI： 10.1128/jb.179.5.1819-1823.1997

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  26 in total

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Authors:  M F Henry; J E Cronan
Journal:  J Mol Biol       Date:  1991-12-20       Impact factor: 5.469

2.  Evidence that the fadB gene of the fadAB operon of Escherichia coli encodes 3-hydroxyacyl-coenzyme A (CoA) epimerase, delta 3-cis-delta 2-trans-enoyl-CoA isomerase, and enoyl-CoA hydratase in addition to 3-hydroxyacyl-CoA dehydrogenase.

Authors:  S Y Yang; J M Li; X Y He; S D Cosloy; H Schulz
Journal:  J Bacteriol       Date:  1988-06       Impact factor: 3.490

Review 3.  Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coli.

Authors:  P N Black; C C DiRusso
Journal:  Biochim Biophys Acta       Date:  1994-01-03

Review 4.  Prevention of drug access to bacterial targets: permeability barriers and active efflux.

Authors:  H Nikaido
Journal:  Science       Date:  1994-04-15       Impact factor: 47.728

5.  Escherichia coli thioesterase I, molecular cloning and sequencing of the structural gene and identification as a periplasmic enzyme.

Authors:  H Cho; J E Cronan
Journal:  J Biol Chem       Date:  1993-05-05       Impact factor: 5.157

6.  Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase.

Authors:  P N Black; C C DiRusso; A K Metzger; T L Heimert
Journal:  J Biol Chem       Date:  1992-12-15       Impact factor: 5.157

7.  Use of Escherichia coli strains containing fad mutations plus a triple plasmid expression system to study the import of myristate, its activation by Saccharomyces cerevisiae acyl-CoA synthetase, and its utilization by S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase.

Authors:  L J Knoll; J I Gordon
Journal:  J Biol Chem       Date:  1993-02-25       Impact factor: 5.157

8.  Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding.

Authors:  N Raman; C C DiRusso
Journal:  J Biol Chem       Date:  1995-01-20       Impact factor: 5.157

9.  A new mechanism of transcriptional regulation: release of an activator triggered by small molecule binding.

Authors:  M F Henry; J E Cronan
Journal:  Cell       Date:  1992-08-21       Impact factor: 41.582

10.  "Protease I" of Escherichia coli functions as a thioesterase in vivo.

Authors:  H Cho; J E Cronan
Journal:  J Bacteriol       Date:  1994-03       Impact factor: 3.490
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  26 in total

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Review 2.  Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.

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Review 3.  The acetate switch.

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Journal:  Microbiol Mol Biol Rev       Date:  2005-03       Impact factor: 11.056

4.  Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids.

Authors:  Fuzhong Zhang; James M Carothers; Jay D Keasling
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5.  Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA.

Authors:  Youjun Feng; John E Cronan
Journal:  J Bacteriol       Date:  2010-07-09       Impact factor: 3.490

6.  Transcriptional Repression of the VC2105 Protein by Vibrio FadR Suggests that It Is a New Auxiliary Member of the fad Regulon.

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7.  Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene.

Authors:  J W Campbell; J E Cronan
Journal:  J Bacteriol       Date:  2001-10       Impact factor: 3.490

8.  Modulation of FadR binding capacity for acyl-CoA fatty acids through structure-guided mutagenesis.

Authors:  John-Paul Bacik; Chris M Yeager; Scott N Twary; Ricardo Martí-Arbona
Journal:  Protein J       Date:  2015-10       Impact factor: 2.371

9.  Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae.

Authors:  Agoston Jerga; Charles O Rock
Journal:  J Biol Chem       Date:  2009-04-17       Impact factor: 5.157

Review 10.  Transcriptional regulation in bacterial membrane lipid synthesis.

Authors:  Yong-Mei Zhang; Charles O Rock
Journal:  J Lipid Res       Date:  2008-10-21       Impact factor: 5.922
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