Literature DB >> 1722255

Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation.

M F Henry1, J E Cronan.   

Abstract

The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible beta-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.

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Year:  1991        PMID: 1722255     DOI: 10.1016/0022-2836(91)90574-p

Source DB:  PubMed          Journal:  J Mol Biol        ISSN: 0022-2836            Impact factor:   5.469


  44 in total

1.  Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters.

Authors:  Youjun Feng; John E Cronan
Journal:  Mol Microbiol       Date:  2011-02-21       Impact factor: 3.501

2.  DevA, a GntR-like transcriptional regulator required for development in Streptomyces coelicolor.

Authors:  Paul A Hoskisson; Sebastien Rigali; Kay Fowler; Kim C Findlay; Mark J Buttner
Journal:  J Bacteriol       Date:  2006-07       Impact factor: 3.490

3.  Synthetic biosensors for precise gene control and real-time monitoring of metabolites.

Authors:  Jameson K Rogers; Christopher D Guzman; Noah D Taylor; Srivatsan Raman; Kelley Anderson; George M Church
Journal:  Nucleic Acids Res       Date:  2015-07-07       Impact factor: 16.971

4.  Role of the Escherichia coli FadR regulator in stasis survival and growth phase-dependent expression of the uspA, fad, and fab genes.

Authors:  A Farewell; A A Diez; C C DiRusso; T Nyström
Journal:  J Bacteriol       Date:  1996-11       Impact factor: 3.490

5.  Regulated expression of a repressor protein: FadR activates iclR.

Authors:  L Gui; A Sunnarborg; D C LaPorte
Journal:  J Bacteriol       Date:  1996-08       Impact factor: 3.490

6.  In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor.

Authors:  J E Cronan
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

7.  Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.

Authors:  Gustavo E Schujman; Marcelo Guerin; Alejandro Buschiazzo; Francis Schaeffer; Leticia I Llarrull; Georgina Reh; Alejandro J Vila; Pedro M Alzari; Diego de Mendoza
Journal:  EMBO J       Date:  2006-08-24       Impact factor: 11.598

8.  Resistance to trifluoroperazine, a calmodulin inhibitor, maps to the fabD locus in Escherichia coli.

Authors:  N Bouquin; M Tempête; I B Holland; S J Séror
Journal:  Mol Gen Genet       Date:  1995-03-10

9.  Role of fadR and atoC(Con) mutations in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in recombinant pha+ Escherichia coli.

Authors:  H G Rhie; D Dennis
Journal:  Appl Environ Microbiol       Date:  1995-07       Impact factor: 4.792

10.  DesT coordinates the expression of anaerobic and aerobic pathways for unsaturated fatty acid biosynthesis in Pseudomonas aeruginosa.

Authors:  Chitra Subramanian; Charles O Rock; Yong-Mei Zhang
Journal:  J Bacteriol       Date:  2010-01       Impact factor: 3.490

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