Literature DB >> 901410

The pathway for the conversion of dihydroagnosterol into cholesterol in rat liver.

I A Tavares, K A Munday, D C Wilton.   

Abstract

Dihydroagnosterol is demethylated by a rat liver homogenate to give 4,4'-dimethylcholesta 7,9-dienol and then cholesta-7,9-dienol. The cholesta-7,9-dienol is isomerized to cholesta-8,14-dienol, which is converted into cholesterol by the normal pathway.

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Year:  1977        PMID： 901410      PMCID： PMC1164950          DOI： 10.1042/bj1660011

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  Synthesis of isomeric 4,4-dimethylcholestenols and identification of a lanosterol metabolite.

Authors:  F GAUTSCHI; K BLOCH
Journal:  J Biol Chem       Date:  1958-12       Impact factor: 5.157

2.  4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol.

Authors:  I A Tavares; K A Munday; D C Wilton
Journal:  Biochem J       Date:  1977-07-15       Impact factor: 3.857

3.  The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

Authors:  D C Wilton; K A Munday; S J Skinner; M Akhtar
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

4.  Investigation of the component reactions of oxidative sterol demethylation. Study of the aerobic and anaerobic processes.

Authors:  W L Miller; M E Kalafer; J L Gaylor; C V Delwiche
Journal:  Biochemistry       Date:  1967-09       Impact factor: 3.162

5.  The conversion of steroid 7,9-dienes into cholesterol.

Authors:  A D Rahimtula; D C Wilton; M Akhtar
Journal:  Biochem J       Date:  1969-05       Impact factor: 3.857

6.  The conversion of cholest-7-en-3beta-ol into cholesterol. General comments on the mechanism of the introduction of double bonds in enzymic reactions.

Authors:  S M Dewhurst; M Akhtar
Journal:  Biochem J       Date:  1967-12       Impact factor: 3.857

7.  The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.

Authors:  I A Watkinson; D C Wilton; K A Munday; M Akhtar
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

8.  The metabolic sequence by which some 4,4-dimethyl sterols are converted into cholesterol.

Authors:  G F Gibbons
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857

9.  A novel olefinic rearrangement. The enzymic conversion of cholesta-7,9-dien-3 -ol into cholesta-8,14-dien-3 -ol.

Authors:  M Akhtar; C W Freeman; A D Rahimtula; D C Wilton
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857

10.  Steroids in newborns and infants. Identification of 24,25-dihydro-delta-9(ll)-lanosterol and 4 alpha, 14 alpha-dimethyl substituted sterols among the esterified and free sterols in human meconium.

Authors:  P Eneroth; J A Gustafsson; E Nyström
Journal:  Eur J Biochem       Date:  1969-12
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  3 in total

1.  Silver ion high pressure liquid chromatography provides unprecedented separation of sterols: application to the enzymatic formation of cholesta-5,8-dien-3 beta-ol.

Authors:  B Ruan; J Shey; N Gerst; W K Wilson; G J Schroepfer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

2.  4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol.

Authors:  I A Tavares; K A Munday; D C Wilton
Journal:  Biochem J       Date:  1977-07-15       Impact factor: 3.857

3.  The metabolism of the fluorescent probe cholesta-5,7,9(11)-trien-3 beta-ol by rat liver.

Authors:  D C Wilton
Journal:  Biochem J       Date:  1982-11-15       Impact factor: 3.857
  3 in total

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