Literature DB >> 4404936

A novel olefinic rearrangement. The enzymic conversion of cholesta-7,9-dien-3 -ol into cholesta-8,14-dien-3 -ol.

M Akhtar, C W Freeman, A D Rahimtula, D C Wilton.   

Abstract

1. [3alpha-(3)H]Cholesta-7,9-dien-3beta-ol is converted in high yield into cholesterol by a 10000g(av.) supernatant fraction of rat liver homogenate. 2. Incubation of cholesta-7,9-dien-3beta-ol with [4-(3)H]NADPH and rat liver microsomal fractions under anaerobic conditions resulted in (3)H being incorporated into the 14alpha-position of cholest-7-en-3beta-ol. 3. Under anaerobic conditions in the absence of NADPH cholesta-7,9-dien-3beta-ol was isomerized into cholesta-8,14-dien-3beta-ol by rat liver microsomal fractions.

Entities:  

Mesh：

Substances：

Year:  1972        PMID： 4404936      PMCID： PMC1174072          DOI： 10.1042/bj1290225

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  6 in total

1.  Biological synthesis of lanosterol and agnosterol.

Authors:  R B CLAYTON; K BLOCH
Journal:  J Biol Chem       Date:  1956-01       Impact factor: 5.157

2.  The substrate activation in some pyridine nucleotide linked enzymic reactions. The conversion of desmosterol into cholesterol.

Authors:  I A Watkinson; D C Wilton; A D Rahimtula; M M Akhtar
Journal:  Eur J Biochem       Date:  1971-11-11

3.  The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

Authors:  D C Wilton; K A Munday; S J Skinner; M Akhtar
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

4.  The conversion of steroid 7,9-dienes into cholesterol.

Authors:  A D Rahimtula; D C Wilton; M Akhtar
Journal:  Biochem J       Date:  1969-05       Impact factor: 3.857

5.  The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.

Authors:  I A Watkinson; D C Wilton; K A Munday; M Akhtar
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

6.  Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate.

Authors:  D P Bloxham; D C Wilton; M Akhtar
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857
  6 in total
  3 in total

1.  The pathway for the conversion of dihydroagnosterol into cholesterol in rat liver.

Authors:  I A Tavares; K A Munday; D C Wilton
Journal:  Biochem J       Date:  1977-07-15       Impact factor: 3.857

2.  The metabolism of the fluorescent probe cholesta-5,7,9(11)-trien-3 beta-ol by rat liver.

Authors:  D C Wilton
Journal:  Biochem J       Date:  1982-11-15       Impact factor: 3.857

3.  Oxysterols: chemical synthesis, biosynthesis and biological activities.

Authors:  E J Parish; V B Nanduri; H H Kohl; F R Taylor
Journal:  Lipids       Date:  1986-01       Impact factor: 1.880
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.