Literature DB >> 8995709

Structure of replicating hepatitis C virus (HCV) quasispecies in the liver may not be reflected by analysis of circulating HCV virions.

B Cabot1, J I Esteban, M Martell, J Genescà, V Vargas, R Esteban, J Guardia, J Gómez.   

Abstract

We have analyzed the population of hepatitis C virus (HCV) sequences in paired liver and serum samples from four patients with chronic hepatitis C. Sequences from three different biopsy specimens from a liver explant from one patient were compared with each other and with the circulating sequences. Our results demonstrate that the circulating quasispecies does not necessarily reflect the viral population replicating in the liver and that this is not due to a macroscopic anatomic compartmentalization of HCV replication. This finding has important implications for the pathogenesis and natural history of chronic HCV infection.

Entities:  

Mesh：

Year:  1997        PMID： 8995709      PMCID： PMC191240     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

Review 1.  Hepatitis C: molecular biology, pathogenesis, epidemiology, clinical features, and prevention.

Authors:  J I Esteban; J Genesca; H J Alter
Journal:  Prog Liver Dis       Date:  1992

2.  Nonhomogeneous distribution of human immunodeficiency virus type 1 proviruses in the spleen.

Authors:  S Delassus; R Cheynier; S Wain-Hobson
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

3.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

4.  Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins.

Authors:  A J Weiner; M J Brauer; J Rosenblatt; K H Richman; J Tung; K Crawford; F Bonino; G Saracco; Q L Choo; M Houghton
Journal:  Virology       Date:  1991-02       Impact factor: 3.616

5.  Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis.

Authors:  N Enomoto; M Kurosaki; Y Tanaka; F Marumo; C Sato
Journal:  J Gen Virol       Date:  1994-06       Impact factor: 3.891

6.  Dynamic behavior of hepatitis C virus quasispecies in patients undergoing orthotopic liver transplantation.

Authors:  M Martell; J I Esteban; J Quer; V Vargas; R Esteban; J Guardia; J Gómez
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

7.  Degree of diversity of hepatitis C virus quasispecies and progression of liver disease.

Authors:  M Honda; S Kaneko; A Sakai; M Unoura; S Murakami; K Kobayashi
Journal:  Hepatology       Date:  1994-11       Impact factor: 17.425

8.  HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes.

Authors:  R Cheynier; S Henrichwark; F Hadida; E Pelletier; E Oksenhendler; B Autran; S Wain-Hobson
Journal:  Cell       Date:  1994-08-12       Impact factor: 41.582

9.  Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.

Authors:  P Farci; H J Alter; D C Wong; R H Miller; S Govindarajan; R Engle; M Shapiro; R H Purcell
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

10.  Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution.

Authors:  M Martell; J I Esteban; J Quer; J Genescà; A Weiner; R Esteban; J Guardia; J Gómez
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103
View more
  17 in total

1.  Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication.

Authors:  T Laskus; M Radkowski; L F Wang; M Nowicki; J Rakela
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Sequence analysis of the hepatitis C virus genome recovered from serum, liver, and peripheral blood mononuclear cells of infected chimpanzees.

Authors:  Y K Shimizu; H Igarashi; T Kanematu; K Fujiwara; D C Wong; R H Purcell; H Yoshikura
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

3.  Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment.

Authors:  F Penin; C Combet; G Germanidis; P O Frainais; G Deléage; J M Pawlotsky
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

4.  The hepatitis C virus 5'UTR genomic region remains highly conserved under HAART: a 4- to 8-year longitudinal study from HCV/HIV co-infected patients.

Authors:  Franco Moretti; Federico Bolcic; Lilia Mammana; Maria Belen Bouzas; Natalia Laufer; Jorge Quarleri
Journal:  AIDS Res Hum Retroviruses       Date:  2010-05       Impact factor: 2.205

5.  Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.

Authors:  Anita Y M Howe; Huiming Cheng; Ian Thompson; Srinivas K Chunduru; Steve Herrmann; John O'Connell; Atul Agarwal; Rajiv Chopra; Alfred M Del Vecchio
Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

6.  Longitudinal evaluation of the structure of replicating and circulating hepatitis C virus quasispecies in nonprogressive chronic hepatitis C patients.

Authors:  B Cabot; M Martell; J I Esteban; M Piron; T Otero; R Esteban; J Guardia; J Gómez
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

7.  Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver.

Authors:  B Cabot; M Martell; J I Esteban; S Sauleda; T Otero; R Esteban; J Guàrdia; J Gómez
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

8.  Vertical Transmission of Hepatitis C Virus: Variable Transmission Bottleneck and Evidence of Midgestation In Utero Infection.

Authors:  Sébastien Fauteux-Daniel; Ariane Larouche; Virginie Calderon; Jonathan Boulais; Chanel Béland; Doris G Ransy; Marc Boucher; Valérie Lamarre; Normand Lapointe; Isabelle Boucoiran; Armelle Le Campion; Hugo Soudeyns
Journal:  J Virol       Date:  2017-11-14       Impact factor: 5.103

9.  Genetic diversity and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients.

Authors:  S Navas; J Martín; J A Quiroga; I Castillo; V Carreño
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

10.  Genetic divergence of hepatitis C virus: the role of HIV-related immunosuppression.

Authors:  Dale M Netski; Qing Mao; Stuart C Ray; Robert S Klein
Journal:  J Acquir Immune Defic Syndr       Date:  2008-10-01       Impact factor: 3.731
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.