Literature DB >> 8986761

Amphipols: polymers that keep membrane proteins soluble in aqueous solutions.

C Tribet1, R Audebert, J L Popot.   

Abstract

Amphipols are a new class of surfactants that make it possible to handle membrane proteins in detergent-free aqueous solution as though they were soluble proteins. The strongly hydrophilic backbone of these polymers is grafted with hydrophobic chains, making them amphiphilic. Amphipols are able to stabilize in aqueous solution under their native state four well-characterized integral membrane proteins: (i) bacteriorhodopsin, (ii) a bacterial photosynthetic reaction center, (iii) cytochrome b6f, and (iv) matrix porin.

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Year:  1996        PMID： 8986761      PMCID： PMC26353          DOI： 10.1073/pnas.93.26.15047

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

Review 1.  Solubilization of membranes by detergents.

Authors:  A Helenius; K Simons
Journal:  Biochim Biophys Acta       Date:  1975-03-25

2.  Isolation and crystallization of bacterial porin.

Authors:  R M Garavito; J P Rosenbusch
Journal:  Methods Enzymol       Date:  1986       Impact factor: 1.600

3.  Secondary electron transfer in reaction centers of Rhodopseudomonas sphaeroides. Out-of-phase periodicity of two for the formation of ubisemiquinone and fully reduced ubiquinone.

Authors:  A Vermeglio
Journal:  Biochim Biophys Acta       Date:  1977-03-11

4.  Purification of bacteriorhodopsin and characterization of mature and partially processed forms.

Authors:  L J Miercke; P E Ross; R M Stroud; E A Dratz
Journal:  J Biol Chem       Date:  1989-05-05       Impact factor: 5.157

5.  Synthesis and characterization of 6-O-(N-heptylcarbamoyl)-methyl-alpha-D-glucopyranoside, a new surfactant for membrane studies.

Authors:  D Plusquellec; G Chevalier; R Talibart; H Wróblewski
Journal:  Anal Biochem       Date:  1989-05-15       Impact factor: 3.365

6.  Detergent binding as a measure of hydrophobic surface area of integral membrane proteins.

Authors:  J V Møller; M le Maire
Journal:  J Biol Chem       Date:  1993-09-05       Impact factor: 5.157

7.  Characterization of the chloroplast cytochrome b6f complex as a structural and functional dimer.

Authors:  D Huang; R M Everly; R H Cheng; J B Heymann; H Schägger; V Sled; T Ohnishi; T S Baker; W A Cramer
Journal:  Biochemistry       Date:  1994-04-12       Impact factor: 3.162

8.  SOME NEW STRUCTURAL ASPECTS AND OLD CONTROVERSIES CONCERNING THE CYTOCHROME b6f COMPLEX OF OXYGENIC PHOTOSYNTHESIS.

Authors:  W. A. Cramer; G. M. Soriano; M. Ponomarev; D. Huang; H. Zhang; S. E. Martinez; J. L. Smith
Journal:  Annu Rev Plant Physiol Plant Mol Biol       Date:  1996-06

9.  Membrane solubilization by a hydrophobic polyelectrolyte: surface activity and membrane binding.

Authors:  J L Thomas; S W Barton; D A Tirrell
Journal:  Biophys J       Date:  1994-09       Impact factor: 4.033

10.  Purification and characterization of the cytochrome b6 f complex from Chlamydomonas reinhardtii.

Authors:  Y Pierre; C Breyton; D Kramer; J L Popot
Journal:  J Biol Chem       Date:  1995-12-08       Impact factor: 5.157
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  166 in total

Review 1.  F1F0-ATP synthase-stalking mind and imagination.

Authors:  S Wilkens
Journal:  J Bioenerg Biomembr       Date:  2000-08       Impact factor: 2.945

2.  Amphiphilic biopolymers (amphibiopols) as new surfactants for membrane protein solubilization.

Authors:  Caroline Duval-Terrié; Pascal Cosette; Gérard Molle; Guy Muller; Emmanuelle Dé
Journal:  Protein Sci       Date:  2003-04       Impact factor: 6.725

Review 3.  Ice breaking in GPCR structural biology.

Authors:  Qiang Zhao; Bei-li Wu
Journal:  Acta Pharmacol Sin       Date:  2012-01-30       Impact factor: 6.150

4.  Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26.

Authors:  Wen-Xu Hong; Kent A Baker; Xingquan Ma; Raymond C Stevens; Mark Yeager; Qinghai Zhang
Journal:  Langmuir       Date:  2010-06-01       Impact factor: 3.882

5.  Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins.

Authors:  Hak Jun Kim; Stanley C Howell; Wade D Van Horn; Young Ho Jeon; Charles R Sanders
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2009-11-01       Impact factor: 9.795

Review 6.  New amphiphiles for membrane protein structural biology.

Authors:  Qinghai Zhang; Houchao Tao; Wen-Xu Hong
Journal:  Methods       Date:  2011-09-20       Impact factor: 3.608

Review 7.  Factors that Influence the Formation and Stability of Thin, Cryo-EM Specimens.

Authors:  Robert M Glaeser; Bong-Gyoon Han; Roseann Csencsits; Alison Killilea; Arto Pulk; Jamie H D Cate
Journal:  Biophys J       Date:  2015-09-17       Impact factor: 4.033

8.  Single-particle electron microscopy in the study of membrane protein structure.

Authors:  Rita De Zorzi; Wei Mi; Maofu Liao; Thomas Walz
Journal:  Microscopy (Oxf)       Date:  2015-10-15       Impact factor: 1.571

9.  Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization.

Authors:  Hyoung Eun Bae; Cristina Cecchetti; Yang Du; Satoshi Katsube; Jonas S Mortensen; Weijiao Huang; Shahid Rehan; Ho Jin Lee; Claus J Loland; Lan Guan; Brian K Kobilka; Bernadette Byrne; Pil Seok Chae
Journal:  Acta Biomater       Date:  2020-06-06       Impact factor: 8.947

10.  Increased immunoaccessibility of MOMP epitopes in a vaccine formulated with amphipols may account for the very robust protection elicited against a vaginal challenge with Chlamydia muridarum.

Authors:  Delia F Tifrea; Sukumar Pal; Jean-Luc Popot; Melanie J Cocco; Luis M de la Maza
Journal:  J Immunol       Date:  2014-04-28       Impact factor: 5.422
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