Literature DB >> 8978040

Is esterase-P encoded by a cryptic pseudogene in Drosophila melanogaster?

E S Balakirev1, F J Ayala.   

Abstract

We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. melanogaster. Est-P would be a "cryptic" pseudogene, in the sense that it retains intact the coding sequence (without stop codons and other alterations usually observed in pseudogenes) in most D. melanogaster strains. We conjecture that the beta-esterase cluster may consist in other Drosophila species of functional and nonfunctional genes. We also conjecture that the rarity of detected pseudogenes in Drosophila may be due to the difficulty of discovering them, because most of them are cryptic.

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Year:  1996        PMID: 8978040      PMCID: PMC1207704     

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  55 in total

1.  Enzyme null alleles in natural populations of Drosophila melanogaster: Frequencies in a North Carolina population.

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Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

2.  High level transcription of the glucocerebrosidase pseudogene in normal subjects and patients with Gaucher disease.

Authors:  J Sorge; E Gross; C West; E Beutler
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Journal:  Mol Biol Evol       Date:  1987-07       Impact factor: 16.240

4.  Unbiased estimation of the rates of synonymous and nonsynonymous substitution.

Authors:  W H Li
Journal:  J Mol Evol       Date:  1993-01       Impact factor: 2.395

Review 5.  A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.

Authors:  W H Li; C I Wu; C C Luo
Journal:  Mol Biol Evol       Date:  1985-03       Impact factor: 16.240

6.  Nonrandom patterns of codon usage and of nucleotide substitutions in human alpha- and beta-globin genes: an evolutionary strategy reducing the rate of mutations with drastic effects?

Authors:  G Modiano; G Battistuzzi; A G Motulsky
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

7.  Pseudogenes as a paradigm of neutral evolution.

Authors:  W H Li; T Gojobori; M Nei
Journal:  Nature       Date:  1981-07-16       Impact factor: 49.962

8.  A gene/pseudogene tandem duplication encodes a cysteine-rich protein expressed during zygote development in Chlamydomonas reinhardtii.

Authors:  G L Matters; U W Goodenough
Journal:  Mol Gen Genet       Date:  1992-03

9.  The structure of the Adh locus of Drosophila mettleri: an intermediate in the evolution of the Adh locus in the repleta group of Drosophila.

Authors:  J S Yum; W T Starmer; D T Sullivan
Journal:  Mol Biol Evol       Date:  1991-11       Impact factor: 16.240

10.  Mitochondrial rps14 is a transcribed and edited pseudogene in Arabidopsis thaliana.

Authors:  D Aubert; C Bisanz-Seyer; M Herzog
Journal:  Plant Mol Biol       Date:  1992-12       Impact factor: 4.076

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  11 in total

1.  Molecular evolution of two linked genes, Est-6 and Sod, in Drosophila melanogaster.

Authors:  E S Balakirev; E I Balakirev; F Rodríguez-Trelles; F J Ayala
Journal:  Genetics       Date:  1999-11       Impact factor: 4.562

2.  Molecular population genetics of the beta-esterase gene cluster of Drosophila melanogaster.

Authors:  Evgeniy S Balakirev; Francisco J Ayala
Journal:  J Genet       Date:  2003-12       Impact factor: 1.166

3.  DNA variation at the Sod locus of Drosophila melanogaster: an unfolding story of natural selection.

Authors:  R R Hudson; A G Sáez; F J Ayala
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

4.  Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes.

Authors:  S Ramos-Onsins; M Aguadé
Journal:  Genetics       Date:  1998-09       Impact factor: 4.562

5.  Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations.

Authors:  Jinghui Zhang; William L Rowe; Andrew G Clark; Kenneth H Buetow
Journal:  Am J Hum Genet       Date:  2003-10-14       Impact factor: 11.025

6.  Nucleotide variation in the tinman and bagpipe homeobox genes of Drosophila melanogaster.

Authors:  Evgeniy S Balakirev; Francisco J Ayala
Journal:  Genetics       Date:  2004-04       Impact factor: 4.562

7.  Nucleotide variation of the Est-6 gene region in natural populations of Drosophila melanogaster.

Authors:  Evgeniy S Balakirev; Francisco J Ayala
Journal:  Genetics       Date:  2003-12       Impact factor: 4.562

8.  DNA polymorphism in the beta-Esterase gene cluster of Drosophila melanogaster.

Authors:  Evgeniy S Balakirev; V R Chechetkin; V V Lobzin; Francisco J Ayala
Journal:  Genetics       Date:  2003-06       Impact factor: 4.562

9.  Birth and death of genes and functions in the beta-esterase cluster of Drosophila.

Authors:  Charles Robin; Lisa M J Bardsley; Chris Coppin; John G Oakeshott
Journal:  J Mol Evol       Date:  2009-06-18       Impact factor: 2.395

10.  Positive and negative selection in the beta-esterase gene cluster of the Drosophila melanogaster subgroup.

Authors:  Evgeniy S Balakirev; Maria Anisimova; Francisco J Ayala
Journal:  J Mol Evol       Date:  2006-03-17       Impact factor: 3.973

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