Literature DB >> 8939869

DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode.

J D Lieb1, E E Capowski, P Meneely, B J Meyer.   

Abstract

The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).

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Year:  1996        PMID： 8939869     DOI： 10.1126/science.274.5293.1732

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  51 in total

1.  The primary sex determination signal of Caenorhabditis elegans.

Authors:  I Carmi; B J Meyer
Journal:  Genetics       Date:  1999-07       Impact factor: 4.562

2.  Evidence for multiple promoter elements orchestrating male-specific regulation of the her-1 gene in Caenorhabditis elegans.

Authors:  W Li; A Streit; B Robertson; W B Wood
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

3.  A molecular link between gene-specific and chromosome-wide transcriptional repression.

Authors:  Diana S Chu; Heather E Dawes; Jason D Lieb; Raymond C Chan; Annie F Kuo; Barbara J Meyer
Journal:  Genes Dev       Date:  2002-04-01       Impact factor: 11.361

Review 4.  The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

Authors:  Ali Shilatifard
Journal:  Annu Rev Biochem       Date:  2012       Impact factor: 23.643

5.  Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene.

Authors:  W G Kelly; S Xu; M K Montgomery; A Fire
Journal:  Genetics       Date:  1997-05       Impact factor: 4.562

Review 6.  Nuclear organization and dosage compensation.

Authors:  Jennifer C Chow; Edith Heard
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-10-13       Impact factor: 10.005

Review 7.  Rings, bracelet or snaps: fashionable alternatives for Smc complexes.

Authors:  Catherine E Huang; Mark Milutinovich; Douglas Koshland
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-03-29       Impact factor: 6.237

8.  Revisiting the X:A signal that specifies Caenorhabditis elegans sexual fate.

Authors:  John M Gladden; Behnom Farboud; Barbara J Meyer
Journal:  Genetics       Date:  2007-10-18       Impact factor: 4.562

9.  A ONECUT homeodomain protein communicates X chromosome dose to specify Caenorhabditis elegans sexual fate by repressing a sex switch gene.

Authors:  John M Gladden; Barbara J Meyer
Journal:  Genetics       Date:  2007-08-24       Impact factor: 4.562

10.  xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1.

Authors:  Balázs Hargitai; Vera Kutnyánszky; Timothy A Blauwkamp; Attila Steták; Györgyi Csankovszki; Krisztina Takács-Vellai; Tibor Vellai
Journal:  Development       Date:  2009-12       Impact factor: 6.868
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