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Literature DB >> 8939555

Chemoreception: tasting the sweet and the bitter.

Abstract

Our understanding of the molecular basis of taste transduction has lagged behind that of other senses, but now a signalling protein-the G protein alpha subunit gustducin-has been shown to be taste-tissue specific and essential for both bitter and sweet tastes.

Mesh：

Substances：
gustducin
Transducin

Year: 1996 PMID： 8939555 DOI： 10.1016/s0960-9822(96)00704-x

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

14 in total

1. Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus.

Authors: T Ogura; A Mackay-Sim; S C Kinnamon
Journal: J Neurosci Date: 1997-05-15 Impact factor: 6.167

2. Prediction of structure and function of G protein-coupled receptors.

Authors: Nagarajan Vaidehi; Wely B Floriano; Rene Trabanino; Spencer E Hall; Peter Freddolino; Eun Jung Choi; Georgios Zamanakos; William A Goddard
Journal: Proc Natl Acad Sci U S A Date: 2002-09-26 Impact factor: 11.205

3. Characterization and solubilization of bitter-responsive receptors that couple to gustducin.

Authors: D Ming; L Ruiz-Avila; R F Margolskee
Journal: Proc Natl Acad Sci U S A Date: 1998-07-21 Impact factor: 11.205

4. Targeted taste cell-specific overexpression of brain-derived neurotrophic factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells, increases taste bud size, and promotes gustatory innervation.

Authors: Irina V Nosrat; Robert F Margolskee; Christopher A Nosrat
Journal: J Biol Chem Date: 2012-03-22 Impact factor: 5.157

Chemoreception: tasting the sweet and the bitter.

1. Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus.

2. Prediction of structure and function of G protein-coupled receptors.

3. Characterization and solubilization of bitter-responsive receptors that couple to gustducin.

4. Targeted taste cell-specific overexpression of brain-derived neurotrophic factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells, increases taste bud size, and promotes gustatory innervation.

Review 5. Evolutionary adaptations to dietary changes.

6. Differential expression of alpha-gustducin in taste bud populations of the rat and hamster.

7. Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha -gustducin.

8. Immunocytochemical analysis of P2X2 in rat circumvallate taste buds.

9. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.

Review 10. Membrane guanylate cyclase, a multimodal transduction machine: history, present, and future directions.