Literature DB >> 893344

Ribosomal suppressors and antisuppressors in Podospora anserina: resistance to cycloheximide.

E Coppin-Raynal.   

Abstract

Informational suppressors and antisuppressors have been previously isolated in Podospora anserina, and a range of exclusively genetic arguments have led to the assumption that they correspond to ribosomal mutations. An in vivo and in vitro comparison of the effect of the ribosomal inhibitor cycloheximide on wildtype and mutant strains described in this paper confirms the ribosomal hypothesis for at least some mutants. Indeed, the four mutants in the AS3 gene were cycloheximide resistant, and their ribosomes were found to be resistant when analyzed by polyuridyl-directed polyphenylalanine systhesis. On the other hand, ribosomes from two su 1 mutants were hypersensitive to the drug.

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Year:  1977        PMID： 893344      PMCID： PMC235544          DOI： 10.1128/jb.131.3.876-883.1977

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

1.  Genetic evidence of ribosomal antisuppressors in Podospora anserina.

Authors:  M Picard-Bennoun
Journal:  Mol Gen Genet       Date:  1976-09-23

2.  Cold-sensitive mutants in Aspergillus nidulans. II. Mutations affecting ribosome production.

Authors:  C Waldron; C F Roberts
Journal:  Mol Gen Genet       Date:  1974

3.  Role of ribosomes in cycloheximide resistance of Neurospora mutants.

Authors:  M Pongratz; W Klingmüller
Journal:  Mol Gen Genet       Date:  1973-08-28

4.  Functional interdependence of 50S and 30S ribosomal subunits.

Authors:  D Apirion; L Saltzman
Journal:  Mol Gen Genet       Date:  1974

5.  Neurospora crassa cytoplasmic ribosomes: isolation and characterization of a cold-sensitive mutant defective in ribosome biosynthesis.

Authors:  S C Schlitt; P J Russell
Journal:  J Bacteriol       Date:  1974-11       Impact factor: 3.490

6.  Identification and functional characterization of the protein controlled by the streptomycin-resistant locus in E. coli.

Authors:  M Ozaki; S Mizushima; M Nomura
Journal:  Nature       Date:  1969-04-26       Impact factor: 49.962

7.  Mutation in Saccharomyces cerevisiae conferring streptomycin and cold sensitivity by affecting ribosome formation and function.

Authors:  F T Bayliss; J L Ingrahm
Journal:  J Bacteriol       Date:  1974-05       Impact factor: 3.490

8.  Genetic analysis of antisuppressor mutants in the fission yeast Schizosaccharomyces pombe.

Authors:  P Thuriaux; M Minet; F Hofer; U Leupold
Journal:  Mol Gen Genet       Date:  1976-12-31

9.  Genetic studies on cycloheximide-resistant strains of Schizosaccharomyces pombe.

Authors:  M A Ibrahim; A Coddington
Journal:  Heredity (Edinb)       Date:  1976-10       Impact factor: 3.821

10.  Cryptopleurine resistance: genetic locus for a 40S ribosomal component in Saccharomyces cerevisiae.

Authors:  P Grant; L Sánchez; A Jiménez
Journal:  J Bacteriol       Date:  1974-12       Impact factor: 3.490
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  9 in total

1.  Change in cytoplasmic ribosome properties during gametogenesis in the alga Chlamydomonas reinhardtii.

Authors:  M Picard-Bennoun; P Bennoun
Journal:  Curr Genet       Date:  1985-03       Impact factor: 3.886

2.  Ribosomal control of translational fidelity in Podospora anserina: A suppressor and an antisuppressor affecting the paromomycin-induced misreading in vitro.

Authors:  E Coppin-Raynal
Journal:  Curr Genet       Date:  1982-05       Impact factor: 3.886

3.  Frameshift suppression by thyA mutants of Escherichia coli K-12.

Authors:  M B Herrington; A Kohli; M Faraci
Journal:  Genetics       Date:  1986-11       Impact factor: 4.562

4.  Analysis of revertants of a ribosomal mutation in Podospora anserina: evidence for new ribosomal mutations which confer hypersensitivity to paromomycin.

Authors:  N Randsholt; F Ibarrondo; M Dequard; M Picard-Bennoun
Journal:  Biochem Genet       Date:  1982-06       Impact factor: 1.890

5.  Mutations affecting translational fidelity in the eucaryote Podospora anserina: characterization of two ribosomal restrictive mutations.

Authors:  M Picard-Bennoun
Journal:  Mol Gen Genet       Date:  1981

6.  Ribosomal suppressors and antisuppressors in Podospora anserina: altered susceptibility to paromomycin and relationships between genetic and phenotypic suppression.

Authors:  E Coppin-Raynal
Journal:  Biochem Genet       Date:  1981-08       Impact factor: 1.890

7.  Cold-sensitivity of a double mutant strain combining two ribosomal mutations in the ascomycete Podospora anserina.

Authors:  M Crouzet; J Bégueret
Journal:  Mol Gen Genet       Date:  1978-10-24

8.  Search for ribosomal mutants in Podospora anserina: genetic analysis of mutants resistant to paromomycin.

Authors:  M Dequard; J L Couderc; P Legrain; L Belcour; M Picard-Bennoun
Journal:  Biochem Genet       Date:  1980-04       Impact factor: 1.890

9.  Every ribosomal suppressor mutation in Aspergillus nidulans has a unique and highly pleiotropic phenotype.

Authors:  R Bratt; S D Martinelli
Journal:  Curr Genet       Date:  1988-07       Impact factor: 3.886
  9 in total

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