Literature DB >> 4612014

Cryptopleurine resistance: genetic locus for a 40S ribosomal component in Saccharomyces cerevisiae.

P Grant, L Sánchez, A Jiménez.   

Abstract

Mutants resistant to the phenanthrene alkaloids tylophorine, tylocrebrine, and cryptopleurine have been isolated from the yeast Saccharomyces cerevisiae. A single recessive nuclear gene was responsible for resistance. This resistance locus, cry, was closely linked to the mating locus (2.2 centimorgans). The resistance was ribosomal and was due to an altered 40S ribosomal subunit. The mode of action of these drugs has been examined, and they appear to inhibit the translocation phase of protein synthesis.

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Year:  1974        PMID： 4612014      PMCID： PMC245916          DOI： 10.1128/jb.120.3.1308-1314.1974

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  21 in total

1.  Chromosome I as a possible site for some rRNA cistrons in Saccharomyces cerevisiae.

Authors:  T B. Øyen
Journal:  FEBS Lett       Date:  1973-02-15       Impact factor: 4.124

2.  Trichodermin resistance--mutation affecting eukaryotic ribosomes.

Authors:  D Schindler; P Grant; J Davies
Journal:  Nature       Date:  1974-04-05       Impact factor: 49.962

3.  Location of ribosomal RNA cistrons in yeast.

Authors:  D B Finkelstein; J Blamire; J Marmur
Journal:  Nat New Biol       Date:  1972-12-27

4.  Bacterial-protein synthesis. A novel system for studying antibiotic action in vivo.

Authors:  D J Burns; E Cundliffe
Journal:  Eur J Biochem       Date:  1973-09-03

5.  Differentiation in vitro by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteria.

Authors:  J M Haslam; P J Davey; A W Linnane; M R Atkinson
Journal:  Biochem Biophys Res Commun       Date:  1968-11-08       Impact factor: 3.575

6.  Isolation of active ribosomal subunits from yeast.

Authors:  B A van der Zeijst; A J Kool; H P Bloemers
Journal:  Eur J Biochem       Date:  1972-10-17

7.  Studies on transfer ribonucleic acid-ribosome complexes. XXI. Effect of antibiotics on peptidyl-puromycin synthesis by mammalian polyribosomes.

Authors:  S Pestka; H Rosenfeld; R Harris; H Hintikka
Journal:  J Biol Chem       Date:  1972-11-10       Impact factor: 5.157

8.  Ribosomal protein conferring sensitivity to the antibiotic spectinomycin in Escherichia coli.

Authors:  A Bollen; J Davies; M Ozaki; S Mizushima
Journal:  Science       Date:  1968-07-04       Impact factor: 47.728

9.  Expression of ribosomal protein genes as analyzed by bacteriophage Mu-induced mutations.

Authors:  M Nomura; F Engbaek
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

10.  Macromolecule synthesis in temperature-sensitive mutants of yeast.

Authors:  L H Hartwell
Journal:  J Bacteriol       Date:  1967-05       Impact factor: 3.490
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  40 in total

1.  Study on proteins from yeast cytoplasmic ribosomes by two-dimensional gel electrophoresis.

Authors:  J Ishiguro
Journal:  Mol Gen Genet       Date:  1976-04-23

2.  Ribosomal suppressors and antisuppressors in Podospora anserina: resistance to cycloheximide.

Authors:  E Coppin-Raynal
Journal:  J Bacteriol       Date:  1977-09       Impact factor: 3.490

Review 3.  Genetic map of Saccharomyces cerevisiae, edition 9.

Authors:  R K Mortimer; D Schild
Journal:  Microbiol Rev       Date:  1985-09

4.  Resistance against cycloheximide in cell lines from Chinese hamster and human cells is conferred by the large subunit of cytoplasmic ribosomes.

Authors:  H Pöche; S Zakrzewski; K H Nierhaus
Journal:  Mol Gen Genet       Date:  1979-09

5.  Expression of cryptopleurine resistance in Saccharomyces cerevisiae.

Authors:  J H Meade; M I Riley; T R Manney
Journal:  J Bacteriol       Date:  1977-03       Impact factor: 3.490

6.  Molecular genetics of cryptopleurine resistance in Saccharomyces cerevisiae: expression of a ribosomal protein gene family.

Authors:  A G Paulovich; J R Thompson; J C Larkin; Z Li; J L Woolford
Journal:  Genetics       Date:  1993-11       Impact factor: 4.562

7.  The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

Authors:  A L Atkin; N Altamura; P Leeds; M R Culbertson
Journal:  Mol Biol Cell       Date:  1995-05       Impact factor: 4.138

8.  DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism.

Authors:  Ying Wang; Wenli Gao; Yuri V Svitkin; Annie Pei-Chun Chen; Yung-Chi Cheng
Journal:  PLoS One       Date:  2010-07-15       Impact factor: 3.240

9.  Genetics and biochemistry of cryptopleurine resistance in the yeast Saccharomyces cerevisiae.

Authors:  L Sánchez; D Vásquez; A Jiménez
Journal:  Mol Gen Genet       Date:  1977-11-18

Review 10.  Antibiotics and compounds affecting tanslation by eukaryotic ribosomes. Specific enhancement of aminoacyl-tRNA binding by methylaxnthines.

Authors:  L Carrasco; C Fernandez-Puentes; D Vazquez
Journal:  Mol Cell Biochem       Date:  1976-02-16       Impact factor: 3.396
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