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Literature DB >> 891350

The chromosome fiber: evidence for an ordered superstructure of nucleosomes.

Abstract

Chromosome fibers isolated from lymphocyte nuclei and prepared for electron microscopy by techniques designed to preserve their native structure have a distinctly knobby appearance, suggesting that DNA and protein are not distributed evenly along the fiber axis. Individual knobs (superbeads) are arranged in tandem and have an average diameter of about 200 A. Mild nuclease digestion of isolated nuclei releases apparent monomer superbeads that are composed of nucleohistone particles with the properties of nucleosomes. The kinetics of digestion indicate that the superbead is a discrete structural unit containing, on the average, about eight nucleosomes.

Entities: Chemical

Mesh：

Substances：

Year: 1977 PMID： 891350 DOI： 10.1007/bf00327030

Source DB: PubMed Journal: Chromosoma ISSN： 0009-5915 Impact factor: 4.316

36 in total

1. Electron microscopic and biochemical evidence that chromatin structure is a repeating unit.

Authors: P Oudet; M Gross-Bellard; P Chambon
Journal: Cell Date: 1975-04 Impact factor: 41.582

2. A comparison of the digestion of nuclei and chromatin by staphylococcal nuclease.

Authors: B Sollner-Webb; G Felsenfeld
Journal: Biochemistry Date: 1975-07 Impact factor: 3.162

3. Nucleas action on chromatin: evidence for discrete, repeated nucleoprotein units along chromatin fibrils.

Authors: D K Oosterhof; J C Hozier; R L Rill
Journal: Proc Natl Acad Sci U S A Date: 1975-02 Impact factor: 11.205

4. Quaternary structure of chromatin.

Authors: S Bram; G Butler-Browne; P Baudy; K Ibel
Journal: Proc Natl Acad Sci U S A Date: 1975-03 Impact factor: 11.205

5. Preparation of native chromatin and damage caused by shearing.

Authors: M Noll; J O Thomas; R D Kornberg
Journal: Science Date: 1975-03-28 Impact factor: 47.728

6. Involvement of histone H1 in the organization of the chromosome fiber.

Authors: M Renz; P Nehls; J Hozier
Journal: Proc Natl Acad Sci U S A Date: 1977-05 Impact factor: 11.205

7. Studies of nuclear acidic proteins. Evidence for their phosphorylation, tissue specificity, selective binding to deoxyribonucleic acid, and stimulation effects on transcription.

Authors: C S Teng; C T Teng; V G Allfrey
Journal: J Biol Chem Date: 1971-06-10 Impact factor: 5.157

8. The nucleolus in primary spermatocytes of Drosophila hydei.

Authors: G F Meyer; W Hennig
Journal: Chromosoma Date: 1974-06-11 Impact factor: 4.316

9. Studies on deoxyribonucleoprotein structure. Redistribution of proteins in mixtures of deoxyribonucleoproteins, DNA and RNA.

Authors: Y V Ilyin; A Y Varshavsky; U N Mickelsaar; G P Georgiev
Journal: Eur J Biochem Date: 1971-09-24

10. On the structure of nucleohistone.

Authors: S Bram; H Ris
Journal: J Mol Biol Date: 1971-02-14 Impact factor: 5.469

36 in total

1. Nucleosome periodicity in HeLa cell chromatin as probed by micrococcal nuclease.

Authors: T R Butt; D B Jump; M E Smulson
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

2. Functional and structural units in the chromomere.

Authors: N A Reznik; G P Yampol; E V Kiseleva; N B Khristolyubova; A D Gruzdev
Journal: Genetica Date: 1991 Impact factor: 1.082

3. Properties of condensed chromatin in barley nuclei.

Authors: A Muller; G Philipps; C Gigot
Journal: Planta Date: 1980-06 Impact factor: 4.116

4. Characterization of a DNA-protein complex and capsomere subunits derived from polyoma virus by treatment with ethyleneglycol-bis-N,N'-tetraacetic acid and dithiothreitol.

Authors: J N Brady; V D Winston; R A Consigli
Journal: J Virol Date: 1978-07 Impact factor: 5.103

9. The superstructure of chromatin and its condensation mechanism. II. Theoretical analysis of the X-ray scattering patterns and model calculations.

Authors: J Bordas; L Perez-Grau; M H Koch; M C Vega; C Nave
Journal: Eur Biophys J Date: 1986 Impact factor: 1.733

10. High-order structure of metaphase chromosomes: evidence for a multiple coiling model.

Authors: T Taniguchi; S Takayama
Journal: Chromosoma Date: 1986 Impact factor: 4.316