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Literature DB >> 8912542

Preliminary findings on the expression of thymosin beta-10 in human breast cancer.

S Verghese-Nikolakaki¹, N Apostolikas, E Livaniou, D S Ithakissios, G P Evangelatos.

Abstract

Paraffin sections from 30 human breast tissue specimens were stained with a specific antibody for thymosin beta-10, ATB10(38-43). The results showed that thymosin beta-10 was detected mainly in the malignant tissue, particularly in the cancerous cells, whereas the normal cell population around the lesions showed very weak staining. Also, the intensity of staining in the cancerous cells was proportionally increased with the increasing grade of the lesions.

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Year: 1996 PMID： 8912542 PMCID： PMC2074777 DOI： 10.1038/bjc.1996.562

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

10 in total

1. Differential expression of thymosin genes in human tumors and in the developing human kidney.

Authors: A K Hall
Journal: Int J Cancer Date: 1991-07-09 Impact factor: 7.396

2. Retinoic acid and serum modulation of thymosin beta-10 gene expression in rat neuroblastoma cells.

Authors: A K Hall
Journal: J Mol Neurosci Date: 1991 Impact factor: 3.444

3. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma.

Authors: A K Hall; J Hempstead; J I Morgan
Journal: Brain Res Mol Brain Res Date: 1990-07

4. Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues.

Authors: E Hannappel; G J Xu; J Morgan; J Hempstead; B L Horecker
Journal: Proc Natl Acad Sci U S A Date: 1982-04 Impact factor: 11.205

5. Amplification-independent overexpression of thymosin beta-10 mRNA in human renal cell carcinoma.

Authors: A K Hall
Journal: Ren Fail Date: 1994 Impact factor: 2.606

6. Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins.

Authors: F X Yu; S C Lin; M Morrison-Bogorad; M A Atkinson; H L Yin
Journal: J Biol Chem Date: 1993-01-05 Impact factor: 5.157

7. Molecular cloning of the cDNA for rat spleen thymosin beta 10 and the deduced amino acid sequence.

Authors: G J Goodall; B L Horecker
Journal: Arch Biochem Biophys Date: 1987-07 Impact factor: 4.013

8. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma.

Authors: M A Weterman; G N van Muijen; D J Ruiter; H P Bloemers
Journal: Int J Cancer Date: 1993-01-21 Impact factor: 7.396

9. Developmental expression of mRNAs encoding thymosins beta 4 and beta 10 in rat brain and other tissues.

Authors: S C Lin; M Morrison-Bogorad
Journal: J Mol Neurosci Date: 1990 Impact factor: 3.444

10. Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes.

Authors: L Cassimeris; D Safer; V T Nachmias; S H Zigmond
Journal: J Cell Biol Date: 1992-12 Impact factor: 10.539

10 in total

7 in total

Preliminary findings on the expression of thymosin beta-10 in human breast cancer.

1. Differential expression of thymosin genes in human tumors and in the developing human kidney.

2. Retinoic acid and serum modulation of thymosin beta-10 gene expression in rat neuroblastoma cells.

3. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma.

4. Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues.

5. Amplification-independent overexpression of thymosin beta-10 mRNA in human renal cell carcinoma.

6. Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins.

7. Molecular cloning of the cDNA for rat spleen thymosin beta 10 and the deduced amino acid sequence.

8. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma.

9. Developmental expression of mRNAs encoding thymosins beta 4 and beta 10 in rat brain and other tissues.

10. Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes.

Review 1. Roles of thymosins in cancers and other organ systems.

2. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.

3. Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response.

4. Suppression of thymosin β10 increases cell migration and metastasis of cholangiocarcinoma.

5. Thymosin beta 10 is a key regulator of tumorigenesis and metastasis and a novel serum marker in breast cancer.

6. Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma.

7. High expression of thymosin beta 10 predicts poor prognosis for hepatocellular carcinoma after hepatectomy.