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Literature DB >> 19194824

Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.

Min Li¹, Yuqing Zhang, Qihui Zhai, Louis W Feurino, William E Fisher, Changyi Chen, Qizhi Yao.

Abstract

Thymosin beta-10 (T beta 10) has been shown to be associated with several cancers; however, its role in pancreatic cancer is not understood. The expression of T beta 10 was determined by immunohistochemistry and real-time polymerase chain reaction. The phosphorylation of JNK and the cytokine secretion was determined by using the Bio-Plex phosphoprotein and cytokines assays. Pancreatic cancer tissues and cells expressed higher amounts of T beta 10 than normal surrounding tissues and human pancreatic duct epithelial cells. Exogenous T beta 10 caused the phosphorylation of JNK and increased the secretion of cytokines interleukin (IL)-7 and IL-8 in BxPC-3 cells. T beta 10 might be a promising marker and a novel therapeutic target for pancreatic cancer.

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Year: 2009 PMID： 19194824 PMCID： PMC2929368 DOI： 10.1080/07357900802254016

Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176

33 in total

1. Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma.

Authors: Michelle L Varney; Sonny L Johansson; Rakesh K Singh
Journal: Am J Clin Pathol Date: 2006-02 Impact factor: 2.493

Review 2. Review of thymic hormones in cancer diagnosis and treatment.

Authors: B Bodey; B Bodey; S E Siegel; H E Kaiser
Journal: Int J Immunopharmacol Date: 2000-04

3. Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival.

Authors: Graziella Bellone; Carlo Smirne; Francesco Angelo Mauri; Elena Tonel; Anna Carbone; Alessandra Buffolino; Luca Dughera; Antonio Robecchi; Mario Pirisi; Giorgio Emanuelli
Journal: Cancer Immunol Immunother Date: 2005-08-11 Impact factor: 6.968

Review 4. Interleukin-8 and human cancer biology.

Authors: K Xie
Journal: Cytokine Growth Factor Rev Date: 2001-12 Impact factor: 7.638

5. Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer: a potential role for interleukin 7.

Authors: Annechien J A Lambeck; Anne P G Crijns; Ninke Leffers; Wim J Sluiter; Klaske A ten Hoor; Mike Braid; Ate G J van der Zee; Toos Daemen; Hans W Nijman; W Martin Kast
Journal: Clin Cancer Res Date: 2007-04-15 Impact factor: 12.531

6. Multiplex analysis of serum cytokines in melanoma patients treated with interferon-alpha2b.

Authors: Zoya R Yurkovetsky; John M Kirkwood; Howard D Edington; Adele M Marrangoni; Lyudmila Velikokhatnaya; Matthew T Winans; Elieser Gorelik; Anna E Lokshin
Journal: Clin Cancer Res Date: 2007-04-15 Impact factor: 12.531

7. Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147.

Authors: Min Li; Qihui Zhai; Uddalak Bharadwaj; Hao Wang; Fei Li; William E Fisher; Changyi Chen; Qizhi Yao
Journal: Cancer Date: 2006-05-15 Impact factor: 6.860

8. Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype.

Authors: H Ouyang; Lj Mou; C Luk; N Liu; J Karaskova; J Squire; M S Tsao
Journal: Am J Pathol Date: 2000-11 Impact factor: 4.307

9. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.

Authors: Min Li; Yuqing Zhang; Zijuan Liu; Uddalak Bharadwaj; Hao Wang; Xinwen Wang; Sheng Zhang; Juan P Liuzzi; Shou-Mei Chang; Robert J Cousins; William E Fisher; F Charles Brunicardi; Craig D Logsdon; Changyi Chen; Qizhi Yao
Journal: Proc Natl Acad Sci U S A Date: 2007-11-14 Impact factor: 11.205

10. Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis.

Authors: Mitsuko Furuya; Takahito Suyama; Hirokazu Usui; Yoshitoshi Kasuya; Mariko Nishiyama; Naotake Tanaka; Isamu Ishiwata; Yuichiro Nagai; Makio Shozu; Sadao Kimura
Journal: Hum Pathol Date: 2007-08-17 Impact factor: 3.466

7 in total

1. Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies.

Authors: Lucía López-Corral; Luis Antonio Corchete; María Eugenia Sarasquete; María Victoria Mateos; Ramón García-Sanz; Encarna Fermiñán; Juan-José Lahuerta; Joan Bladé; Albert Oriol; Ana Isabel Teruel; María Luz Martino; José Hernández; Jesús María Hernández-Rivas; Francisco Javier Burguillo; Jesús F San Miguel; Norma C Gutiérrez
Journal: Haematologica Date: 2014-05-09 Impact factor: 9.941

Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.

1. Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma.

Review 2. Review of thymic hormones in cancer diagnosis and treatment.

3. Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival.

Review 4. Interleukin-8 and human cancer biology.

5. Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer: a potential role for interleukin 7.

6. Multiplex analysis of serum cytokines in melanoma patients treated with interferon-alpha2b.

7. Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147.

8. Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype.

9. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.

10. Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis.

1. Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies.

2. Characterization and probiotic properties of Lactobacilli from human breast milk.

3. Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro-intestinal tract.

4. Suppression of thymosin β10 increases cell migration and metastasis of cholangiocarcinoma.

5. [Thymosin beta 10 prompted the VEGF-C expression in lung cancer cell].

6. Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma.

7. High expression of thymosin beta 10 predicts poor prognosis for hepatocellular carcinoma after hepatectomy.