Literature DB >> 8895469

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23.

M H Polymeropoulos1, J J Higgins, L I Golbe, W G Johnson, S E Ide, G Di Iorio, G Sanges, E S Stenroos, L T Pho, A A Schaffer, A M Lazzarini, R L Nussbaum, R C Duvoisin.   

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.

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Year:  1996        PMID： 8895469     DOI： 10.1126/science.274.5290.1197

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  154 in total

1.  Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson's disease.

Authors:  K Dujardin; A Duhamel; E Becquet; C Grunberg; L Defebvre; A Destee
Journal:  J Neurol Neurosurg Psychiatry       Date:  1999-09       Impact factor: 10.154

Review 2.  A preamble on parkinsonism.

Authors:  E K Koranyi
Journal:  J Psychiatry Neurosci       Date:  1999-09       Impact factor: 6.186

3.  The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.

Authors:  N Ostrerova-Golts; L Petrucelli; J Hardy; J M Lee; M Farer; B Wolozin
Journal:  J Neurosci       Date:  2000-08-15       Impact factor: 6.167

4.  The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.

Authors:  Alexander Zimprich; Bertram Müller-Myhsok; Matthew Farrer; Petra Leitner; Manu Sharma; Mary Hulihan; Paul Lockhart; Audrey Strongosky; Jennifer Kachergus; Donald B Calne; Jon Stoessl; Ryan J Uitti; Ronald F Pfeiffer; Claudia Trenkwalder; Nikolaus Homann; Erwin Ott; Karoline Wenzel; Friedrich Asmus; John Hardy; Zbigniew Wszolek; Thomas Gasser
Journal:  Am J Hum Genet       Date:  2003-12-19       Impact factor: 11.025

Review 5.  Rare genetic mutations shed light on the pathogenesis of Parkinson disease.

Authors:  Ted M Dawson; Valina L Dawson
Journal:  J Clin Invest       Date:  2003-01       Impact factor: 14.808

Review 6.  The genetic basis of Parkinson's disease.

Authors:  T Foltynie; S Sawcer; C Brayne; R A Barker
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-10       Impact factor: 10.154

7.  Parkinson's disease in China.

Authors:  You-yong Tian; Cui-ju Tang; Jie Wu; Jun-shan Zhou
Journal:  Neurol Sci       Date:  2010-12-14       Impact factor: 3.307

Review 8.  Genetics and phenotyping of urological chronic pelvic pain syndrome.

Authors:  Jordan Dimitrakov; David Guthrie
Journal:  J Urol       Date:  2009-02-23       Impact factor: 7.450

Review 9.  Autophagy in Parkinson's Disease.

Authors:  Xu Hou; Jens O Watzlawik; Fabienne C Fiesel; Wolfdieter Springer
Journal:  J Mol Biol       Date:  2020-02-13       Impact factor: 5.469

Review 10.  Parkinson's disease and enhanced inflammatory response.

Authors:  Iva Stojkovska; Brandon M Wagner; Brad E Morrison
Journal:  Exp Biol Med (Maywood)       Date:  2015-03-13
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