Literature DB >> 8893788

Detection of apoptosis induced in peripheral blood lymphocytes from cats infected with feline immunodeficiency virus.

Y Momoi1, T Mizuno, Y Nishimura, Y Endo, K Ohno, T Watari, R Goitsuka, H Tsujimoto, A Hasegawa.   

Abstract

Peripheral blood lymphocytes (PBL) from cats infected with feline immunodeficiency virus (FIV) were examined for the occurrence of apoptosis after short-term culture. In the PBL from FIV-infected cats, changes in flow-cytometry scattergram, morphological characteristics of apoptosis and nucleosomal DNA fragmentation were observed. Percentages of apoptotic cells by flowcytometry analysis in PBL from FIV-infected cats (22.4% +/- 9.4%) were significantly higher than those in PBL from uninfected control cats (9.2% +/- 3.5%). The lymphocytes which underwent apoptosis included CD5+, CD4+ and sIgM+ cells, indicating that induction of apoptosis was not restricted to a special subset of lymphocytes. These findings provide evidence of the apoptotic state of PBL in cats with FIV infection.

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Year:  1996        PMID： 8893788     DOI： 10.1007/bf01718289

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  19 in total

1.  Detection of feline T-lymphotropic lentivirus (FTLV) infection in Japanese domestic cats.

Authors:  T Ishida; T Washizu; K Toriyabe; S Motoyoshi
Journal:  Nihon Juigaku Zasshi       Date:  1988-02

2.  Altered mitogen response of peripheral blood lymphocytes in different stages of feline immunodeficiency virus infection.

Authors:  A Taniguchi; T Ishida; A Konno; T Washizu; I Tomoda
Journal:  Nihon Juigaku Zasshi       Date:  1990-06

3.  Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus.

Authors:  K Ohno; Y Okamoto; T Miyazawa; T Mikami; T Watari; R Goitsuka; H Tsujimoto; A Hasegawa
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

4.  Decreased mitogen responsiveness and elevated tumor necrosis factor production in cats shortly after feline immunodeficiency virus infection.

Authors:  C E Lawrence; J J Callanan; O Jarrett
Journal:  Vet Immunol Immunopathol       Date:  1992-12       Impact factor: 2.046

5.  Tumor necrosis factor alpha levels in cats experimentally infected with feline immunodeficiency virus: effects of immunization and feline leukemia virus infection.

Authors:  R Lehmann; H Joller; B L Haagmans; H Lutz
Journal:  Vet Immunol Immunopathol       Date:  1992-12       Impact factor: 2.046

6.  A recombinant feline immunodeficiency virus envelope fusion protein stimulates peripheral blood lymphocytes from naive cats to proliferate in vitro.

Authors:  J A Beatty; G Reid; M A Rigby; J C Neil; O Jarrett; M J Browning
Journal:  Vet Immunol Immunopathol       Date:  1992-12       Impact factor: 2.046

7.  Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometric method.

Authors:  M Carbonari; M Cibati; M Cherchi; D Sbarigia; A M Pesce; L Dell'Anna; A Modica; M Fiorilli
Journal:  Blood       Date:  1994-03-01       Impact factor: 22.113

8.  Nucleotide sequence and genomic organization of feline immunodeficiency virus.

Authors:  R L Talbott; E E Sparger; K M Lovelace; W M Fitch; N C Pedersen; P A Luciw; J H Elder
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

9.  Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus.

Authors:  C D Ackley; J K Yamamoto; N Levy; N C Pedersen; M D Cooper
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

10.  Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome.

Authors:  N C Pedersen; E W Ho; M L Brown; J K Yamamoto
Journal:  Science       Date:  1987-02-13       Impact factor: 47.728
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  2 in total

1.  The use of two immunosuppressive drugs, cyclosporin A and tacrolimus, to inhibit virus replication and apoptosis in cells infected with feline immunodeficiency virus.

Authors:  E Mortola; Y Endo; K Ohno; T Watari; H Tsujimoto; A Hasegawa
Journal:  Vet Res Commun       Date:  1998-12       Impact factor: 2.459

2.  The role of in vitro-induced lymphocyte apoptosis in feline immunodeficiency virus infection: correlation with different markers of disease progression.

Authors:  E Holznagel; R Hofmann-Lehmann; C M Leutenegger; K Allenspach; S Huettner; U Forster; E Niederer; H Joller; B J Willett; U Hummel; G L Rossi; J Schüpbach; H Lutz
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103
  2 in total

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