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Literature DB >> 8198440

Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus.

K Ohno¹, Y Okamoto, T Miyazawa, T Mikami, T Watari, R Goitsuka, H Tsujimoto, A Hasegawa.

Abstract

The mechanism of cell death induced by feline immunodeficiency virus (FIV) infection was investigated in an interleukin 2(IL-2)-dependent T-lymphoblastoid cell line (MYA-1). DNA extracted from FIV-infected MYA-1 cells showed a ladder of nucleosomal DNA, indicating that the cytopathic effect (CPE) observed in these cells was due to apoptosis. Infection of MYA-1 cells with FIV was associated with suppression of the proliferative response of the cells to exogenous IL-2 prior to DNA fragmentation. These findings suggest that FIV-induced CPE in these T-lymphoblastoid cells is associated with apoptosis possibly due to a defect in the IL-2 signal transduction pathway.

Entities: Disease Species

Mesh：

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Year: 1994 PMID： 8198440 DOI： 10.1007/bf01309772

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

23 in total

1. Production of a monoclonal antibody that defines the alpha-subunit of the feline IL-2 receptor.

Authors: K Ohno; R Goitsuka; K Kitamura; A Hasegawa; T Tokunaga; M Honda
Journal: Hybridoma Date: 1992-10

2. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures.

Authors: C A Smith; G T Williams; R Kingston; E J Jenkinson; J J Owen
Journal: Nature Date: 1989-01-12 Impact factor: 49.962

3. Defective T-cell colony formation and IL-2 receptor expression at all stages of HIV infection.

Authors: A Winkelstein; L A Kingsley; R S Klein; D W Lyter; T L Evans; C R Rinaldo; L D Weaver; L L Machen; R C Schadle
Journal: Clin Exp Immunol Date: 1988-03 Impact factor: 4.330

4. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.

Authors: A H Wyllie
Journal: Nature Date: 1980-04-10 Impact factor: 49.962

5. Development of IL-2-independent feline lymphoid cell lines chronically infected with feline immunodeficiency virus: importance for diagnostic reagents and vaccines.

Authors: J K Yamamoto; C D Ackley; H Zochlinski; H Louie; E Pembroke; M Torten; H Hansen; R Munn; T Okuda
Journal: Intervirology Date: 1991 Impact factor: 1.763

6. Depressed interleukin 2 receptor expression in acquired immune deficiency and lymphadenopathy syndromes.

Authors: H E Prince; V Kermani-Arab; J L Fahey
Journal: J Immunol Date: 1984-09 Impact factor: 5.422

7. Molecular cloning of feline immunodeficiency virus.

Authors: R A Olmsted; A K Barnes; J K Yamamoto; V M Hirsch; R H Purcell; P R Johnson
Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205

8. A major mechanism of human immunodeficiency virus-induced cell killing does not involve cell fusion.

Authors: M Somasundaran; H L Robinson
Journal: J Virol Date: 1987-10 Impact factor: 5.103

9. Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus.

Authors: C D Ackley; J K Yamamoto; N Levy; N C Pedersen; M D Cooper
Journal: J Virol Date: 1990-11 Impact factor: 5.103

10. Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

Authors: H Groux; G Torpier; D Monté; Y Mouton; A Capron; J C Ameisen
Journal: J Exp Med Date: 1992-02-01 Impact factor: 14.307

11 in total

1. Rhabdovirus-induced apoptosis in a fish cell line is inhibited by a human endogenous acid cysteine proteinase inhibitor.

Authors: H V Björklund; T R Johansson; A Rinne
Journal: J Virol Date: 1997-07 Impact factor: 5.103

2. Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence.

Authors: J Lewis; S L Wesselingh; D E Griffin; J M Hardwick
Journal: J Virol Date: 1996-03 Impact factor: 5.103

3. Detection of apoptosis induced in peripheral blood lymphocytes from cats infected with feline immunodeficiency virus.

Authors: Y Momoi; T Mizuno; Y Nishimura; Y Endo; K Ohno; T Watari; R Goitsuka; H Tsujimoto; A Hasegawa
Journal: Arch Virol Date: 1996 Impact factor: 2.574

4. Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity.

Authors: M Itoh; H Hotta; M Homma
Journal: J Virol Date: 1998-04 Impact factor: 5.103

5. The use of two immunosuppressive drugs, cyclosporin A and tacrolimus, to inhibit virus replication and apoptosis in cells infected with feline immunodeficiency virus.

Authors: E Mortola; Y Endo; K Ohno; T Watari; H Tsujimoto; A Hasegawa
Journal: Vet Res Commun Date: 1998-12 Impact factor: 2.459