Literature DB >> 1976826

Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus.

C D Ackley1, J K Yamamoto, N Levy, N C Pedersen, M D Cooper.   

Abstract

Blood mononuclear cells from 47 cats experimentally infected with feline immunodeficiency virus (FIV) were examined by using monoclonal antibodies directed against feline CD4 and CD8 homologs, a pan-T-cell antigen, and cell surface immunoglobulin. Significant inversion of the CD4+/CD8+ T-cell ratio was observed only in cats that were infected for 18 months or more. This inversion was associated with a decrease in the absolute numbers of CD4+ T cells and a concomitant increase in CD8+ cells. However, the total numbers of circulating T and B cells were not significantly reduced. Cats infected with FIV for 24 to 28 months also had significantly elevated levels of serum immunoglobulin G (IgG), but normal levels of IgA and IgM. The long-term decline in CD4+ T cells and hypergammaglobulinemia observed in FIV-infected cats resemble the abnormalities occurring in humans after human immunodeficiency virus infection.

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Year:  1990        PMID： 1976826      PMCID： PMC248623     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Identification of a CD4 homologue in the cat.

Authors:  C D Ackley; E A Hoover; M D Cooper
Journal:  Tissue Antigens       Date:  1990-02

2.  A feline thymocyte antigen defined by a monoclonal antibody (FT2) identifies a subpopulation of non-helper cells capable of specific cytotoxicity.

Authors:  F W Klotz; M D Cooper
Journal:  J Immunol       Date:  1986-04-01       Impact factor: 5.422

3.  Feline immunodeficiency virus infection in cats of Japan.

Authors:  T Ishida; T Washizu; K Toriyabe; S Motoyoshi; I Tomoda; N C Pedersen
Journal:  J Am Vet Med Assoc       Date:  1989-01-15       Impact factor: 1.936

4.  B-cell immunodeficiency in acquired immune deficiency syndrome.

Authors:  A J Ammann; G Schiffman; D Abrams; P Volberding; J Ziegler; M Conant
Journal:  JAMA       Date:  1984-03-16       Impact factor: 56.272

5.  Molecular cloning of feline immunodeficiency virus.

Authors:  R A Olmsted; A K Barnes; J K Yamamoto; V M Hirsch; R H Purcell; P R Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

6.  Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats.

Authors:  J K Yamamoto; E Sparger; E W Ho; P R Andersen; T P O'Connor; C P Mandell; L Lowenstine; R Munn; N C Pedersen
Journal:  Am J Vet Res       Date:  1988-08       Impact factor: 1.156

7.  Monoclonal vs. heterogeneous anti-H-8 antibodies in the analysis of the anti-phosphorylcholine response in BALB/c mice.

Authors:  J F Kearney; R Barletta; Z S Quan; J Quintáns
Journal:  Eur J Immunol       Date:  1981-11       Impact factor: 5.532

8.  Development and distribution of B lineage cells in the domestic cat: analysis with monoclonal antibodies to cat mu-, gamma-, kappa-, and lambda-chains and heterologous anti-alpha antibodies.

Authors:  F W Klotz; W E Gathings; M D Cooper
Journal:  J Immunol       Date:  1985-01       Impact factor: 5.422

9.  Chicken thymocyte-specific antigen identified by monoclonal antibodies: ontogeny, tissue distribution and biochemical characterization.

Authors:  C H Chen; T C Chanh; M D Cooper
Journal:  Eur J Immunol       Date:  1984-05       Impact factor: 5.532

10.  Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome.

Authors:  N C Pedersen; E W Ho; M L Brown; J K Yamamoto
Journal:  Science       Date:  1987-02-13       Impact factor: 47.728
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  102 in total

1.  Blocking of feline immunodeficiency virus infection by a monoclonal antibody to CD9 is via inhibition of virus release rather than interference with receptor binding.

Authors:  A de Parseval; D L Lerner; P Borrow; B J Willett; J H Elder
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Detection of salivary antibodies in cats infected with feline immunodeficiency virus.

Authors:  A Poli; C Giannelli; M Pistello; L Zaccaro; D Pieracci; M Bendinelli; G Malvaldi
Journal:  J Clin Microbiol       Date:  1992-08       Impact factor: 5.948

3.  In vivo lymphocyte tropism of feline immunodeficiency virus.

Authors:  R V English; C M Johnson; D H Gebhard; M B Tompkins
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

4.  Multiple-drug-resistant mutants of feline immunodeficiency virus selected with 2',3'-dideoxyinosine alone and in combination with 3'-azido-3'-deoxythymidine.

Authors:  J M Gobert; K M Remington; Y Q Zhu; T W North
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

5.  Circulating immune complexes and analysis of renal immune deposits in feline immunodeficiency virus-infected cats.

Authors:  A Poli; M L Falcone; L Bigalli; C Massi; R Hofmann-Lehmann; S Lombardi; M Bendinelli; H Lutz
Journal:  Clin Exp Immunol       Date:  1995-08       Impact factor: 4.330

Review 6.  Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.

Authors:  M Bendinelli; M Pistello; S Lombardi; A Poli; C Garzelli; D Matteucci; L Ceccherini-Nelli; G Malvaldi; F Tozzini
Journal:  Clin Microbiol Rev       Date:  1995-01       Impact factor: 26.132

7.  Haematological and lymphocyte subset analyses in sheep inoculated with bovine immunodeficiency-like virus.

Authors:  R M Jacobs; H E Smith; C A Whetstone; D L Suarez; B Jefferson; V E Valli
Journal:  Vet Res Commun       Date:  1994       Impact factor: 2.459

8.  Mapping of Receptor Binding Interactions with the FIV surface Glycoprotein (SU); Implications Regarding Immune surveillance and cellular Targets of Infection.

Authors:  Qiong-Ying Hu; Elizabeth Fink; John H Elder
Journal:  Retrovirology (Auckl)       Date:  2012-07-11

9.  Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor.

Authors:  Aymeric de Parseval; Udayan Chatterji; Peiqing Sun; John H Elder
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-23       Impact factor: 11.205

10.  Localization of the viral antigen of feline immunodeficiency virus in the lymph nodes of cats at the early stage of infection.

Authors:  T Toyosaki; T Miyazawa; T Furuya; K Tomonaga; Y S Shin; M Okita; Y Kawaguchi; C Kai; S Mori; T Mikami
Journal:  Arch Virol       Date:  1993       Impact factor: 2.574
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