Literature DB >> 887500

Stimulatory and inhibitory action of clonidine on the locomotor activity in the rat.

B Bednarczyk, J Vetulani.   

Abstract

Clonidine depresses "motivated" but stimulates "basal" locomotor activity of normal rats. It does not affect the "dopaminergic", but inhibits "noradrenergic" locomotor stimulation produced by intraventricularly administered L-dopa methyl ester to nialamide-pretreated rats, although it does not affect the brain norepinephrine accumulation observed after administration of the dopa derivative. The importance of experimental protocol and the possible mechanism of "antiadrenergic" action of clonidine are discussed.

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Year:  1977        PMID： 887500

Source DB:  PubMed          Journal:  Pol J Pharmacol Pharm        ISSN： 0301-0244


  6 in total

1.  Motor depression and head twitches induced by IP injection of GABA.

Authors:  A Smiałowski; M Smiałowska; K Reichenberg; B Byrska; J Vetulani
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

Review 2.  A possible physiological role for cerebral tetrahydroisoquinolines.

Authors:  Jerzy Vetulani; Lucyna Antkiewicz-Michaluk; Irena Nalepa; Mario Sansone
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

3.  Lesion of serotonergic neurons antagonizes clonidine induced suppression of avoidance behavior and locomotor activity in rats.

Authors:  W Kostowski; A Plaznik; O Pucilowski; A Bidzinski; M Hauptmann
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

4.  Modulation of rat brain alpha-adrenoreceptor populations four weeks after stimulation of the nucleus locus coeruleus.

Authors:  L Velley; B Cardo; J Bockaert
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

5.  Effect of clonidine and phentolamine on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in mice.

Authors:  P Cazala
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

6.  Differential involvement of voltage-dependent calcium channels in apomorphine-induced hypermotility and stereotypy.

Authors:  L Antkiewicz-Michaluk; J Michaluk; I Romańska; J Vetulani
Journal:  Psychopharmacology (Berl)       Date:  1994-01       Impact factor: 4.530
  6 in total

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