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Literature DB >> 6787646

Lesion of serotonergic neurons antagonizes clonidine induced suppression of avoidance behavior and locomotor activity in rats.

W Kostowski, A Plaznik, O Pucilowski, A Bidzinski, M Hauptmann.

Abstract

The effects of clonidine on avoidance acquisition and locomotor activity were studied in male Wistar rats with 5,6-dihydroxytryptamine (5,6-DHT) lesions of the median raphe nucleus. Lesioned animals showed marked depletion in forebrain serotonin and 5-hydroxyindole acetic acid concentrations. clonidine (0.2 mg/kg IP in a single daily dose for 6 consecutive days) inhibited avoidance acquisition and reduced locomotor activity in unlesioned rats. In 5,6-DHT rats clonidine failed to produce depressive effect. The resistance of raphe-lesioned rats to clonidine is discussed on the basis of possible interaction between noradrenergic and serotonergic brain systems.

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Year: 1981 PMID： 6787646 DOI： 10.1007/BF00422414

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

27 in total

1. Pharmacological characterization of alpha-adrenoceptors which mediate clonidine-induced sedation [proceedings].

Authors: G M Drew; A J Gower; A S Marriott
Journal: Br J Pharmacol Date: 1977-11 Impact factor: 8.739

2. Depression of exploratory activity by clonidine in rats as a model for the detection of relative pre- and postsynaptic central noradrenergic receptor selectivity of alpha-adrenolytic drugs.

Authors: A Delini-Stula; P Baumann; O Büch
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-06 Impact factor: 3.000

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Authors: R D Robson; M J Antonaccio; J K Saelens; J Liebman
Journal: Eur J Pharmacol Date: 1978-02-15 Impact factor: 4.432

4. 5,7-dihydroxytryptamine: improvement in chemical lesioning of indoleamine neurons in the mammalian brain.

Authors: H G Baumgarten; L Lachenmayer
Journal: Z Zellforsch Mikrosk Anat Date: 1972

5. Selective potentiation of locomotor effects of amphetamine by midbrain raphé lesions.

Authors: D B Neill; L D Grant; S P Grossman
Journal: Physiol Behav Date: 1972-10

6. Simultaneous extraction and fluorometric measurement of brain serotonin, catecholamines, 5-hydroxy-indoleacetic acid and homovanillic acid.

Authors: D R Haubrich; J S Denzer
Journal: Anal Biochem Date: 1973-09 Impact factor: 3.365

7. Studies on behavioural and biochemical changes in rats after lesion of midbrain raphé.

Authors: W Kostowski; E Giacalone; S Garattini; L Valzelli
Journal: Eur J Pharmacol Date: 1968-11 Impact factor: 4.432

8. Inhibition of adrenergic neurotransmission by clonidine: an action on prejunctional -receptors.

Authors: K Starke; K P Altmann
Journal: Neuropharmacology Date: 1973-04 Impact factor: 5.250

9. Ascending 5-HT pathways and behavioural habituation.

Authors: J F Deakin; S E File; J R Hyde; N K Macleod
Journal: Pharmacol Biochem Behav Date: 1979-05 Impact factor: 3.533

10. Activity, avoidance learning and regional 5-hydroxytryptamine following intra-brain stem 5,7-dihydroxytryptamine and electrolytic midbrain raphe lesions in the rat.

Authors: S A Lorens; H C Guldberg; K Hole; C Köhler; B Srebro
Journal: Brain Res Date: 1976-05-21 Impact factor: 3.252

4 in total

4. Antagonism of behavioural depression produced by clonidine in the Mongolian gerbil: a potential screening test for antidepressant drugs.

Authors: W Kostowski; E Malatyńska
Journal: Psychopharmacology (Berl) Date: 1983 Impact factor: 4.530